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Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi
Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung c...
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Published in: | PloS one 2020-09, Vol.15 (9), p.e0238509-e0238509 |
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creator | Khoonrit, Pichayatri Mirdogan, Alp Dehlinger, Adeline Mekboonsonglarp, Wanwimon Likhitwitayawuid, Kittisak Priller, Josef Böttcher, Chotima Sritularak, Boonchoo |
description | Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung cancer. However, it remains to be determined whether these therapeutic effects can be also seen in primary human cells and/or in vivo. In this study, we comparatively investigated the immune modulatory effects of bibenzyls and phenanthrenes, including a novel Dendrobium bibenzyl derivative, in primary human monocytes. All compounds were isolated and purified from a Thai orchid Dendrobium lindleyi Steud, a new source of therapeutic compounds with promising potential of tissue culture production. We detected increased frequencies of TNF- and IL-6-expressing monocytes after treatment with gigantol and cypripedin, whereas chrysotoxine and moscatilin did not alter the expression of these cytokines in monocytes. Interestingly, the new 4,5-dihydroxy-3,3',4'-trimethoxybibenzyl derivative showed dose-dependent immune modulatory effects in lipopolysaccharide (LPS)-treated CD14.sup.lo and CD14.sup.hi monocytes. Together, our findings show immune modulatory effects of the new bibenzyl derivative from Dendrobium lindleyi on different monocyte sub-populations. However, therapeutic consequences of these different monocyte populations on human diseases including cancer remain to be investigated. |
doi_str_mv | 10.1371/journal.pone.0238509 |
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However, it remains to be determined whether these therapeutic effects can be also seen in primary human cells and/or in vivo. In this study, we comparatively investigated the immune modulatory effects of bibenzyls and phenanthrenes, including a novel Dendrobium bibenzyl derivative, in primary human monocytes. All compounds were isolated and purified from a Thai orchid Dendrobium lindleyi Steud, a new source of therapeutic compounds with promising potential of tissue culture production. We detected increased frequencies of TNF- and IL-6-expressing monocytes after treatment with gigantol and cypripedin, whereas chrysotoxine and moscatilin did not alter the expression of these cytokines in monocytes. Interestingly, the new 4,5-dihydroxy-3,3',4'-trimethoxybibenzyl derivative showed dose-dependent immune modulatory effects in lipopolysaccharide (LPS)-treated CD14.sup.lo and CD14.sup.hi monocytes. Together, our findings show immune modulatory effects of the new bibenzyl derivative from Dendrobium lindleyi on different monocyte sub-populations. However, therapeutic consequences of these different monocyte populations on human diseases including cancer remain to be investigated.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0238509</identifier><identifier>PMID: 32870935</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Blood & organ donations ; Care and treatment ; Cell culture ; Chemical compounds ; Chemical properties ; Chemokines ; Chromatography ; Chronic illnesses ; Cytokines ; Dendrobium ; Health aspects ; Herbal medicine ; In vivo methods and tests ; Inflammation ; Interleukin 6 ; Laboratories ; Lipopolysaccharides ; Lung cancer ; Lung diseases ; Medicine and Health Sciences ; Metabolites ; Metastases ; Metastasis ; Methods ; Monocytes ; Orchids ; Pathogens ; Pharmaceutical sciences ; Pharmacology ; Plant extracts ; Plant metabolites ; Populations ; Psychiatry ; Research and analysis methods ; Testing ; Tissue culture ; Tumor necrosis factor</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0238509-e0238509</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Khoonrit et al. 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Alp</au><au>Dehlinger, Adeline</au><au>Mekboonsonglarp, Wanwimon</au><au>Likhitwitayawuid, Kittisak</au><au>Priller, Josef</au><au>Böttcher, Chotima</au><au>Sritularak, Boonchoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi</atitle><jtitle>PloS one</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0238509</spage><epage>e0238509</epage><pages>e0238509-e0238509</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors declare no competing financial interests.</notes><abstract>Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung cancer. However, it remains to be determined whether these therapeutic effects can be also seen in primary human cells and/or in vivo. In this study, we comparatively investigated the immune modulatory effects of bibenzyls and phenanthrenes, including a novel Dendrobium bibenzyl derivative, in primary human monocytes. All compounds were isolated and purified from a Thai orchid Dendrobium lindleyi Steud, a new source of therapeutic compounds with promising potential of tissue culture production. We detected increased frequencies of TNF- and IL-6-expressing monocytes after treatment with gigantol and cypripedin, whereas chrysotoxine and moscatilin did not alter the expression of these cytokines in monocytes. Interestingly, the new 4,5-dihydroxy-3,3',4'-trimethoxybibenzyl derivative showed dose-dependent immune modulatory effects in lipopolysaccharide (LPS)-treated CD14.sup.lo and CD14.sup.hi monocytes. Together, our findings show immune modulatory effects of the new bibenzyl derivative from Dendrobium lindleyi on different monocyte sub-populations. However, therapeutic consequences of these different monocyte populations on human diseases including cancer remain to be investigated.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32870935</pmid><doi>10.1371/journal.pone.0238509</doi><tpages>e0238509</tpages><orcidid>https://orcid.org/0000-0002-6226-586X</orcidid><orcidid>https://orcid.org/0000-0001-7145-8367</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biology and Life Sciences Blood & organ donations Care and treatment Cell culture Chemical compounds Chemical properties Chemokines Chromatography Chronic illnesses Cytokines Dendrobium Health aspects Herbal medicine In vivo methods and tests Inflammation Interleukin 6 Laboratories Lipopolysaccharides Lung cancer Lung diseases Medicine and Health Sciences Metabolites Metastases Metastasis Methods Monocytes Orchids Pathogens Pharmaceutical sciences Pharmacology Plant extracts Plant metabolites Populations Psychiatry Research and analysis methods Testing Tissue culture Tumor necrosis factor |
title | Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T15%3A16%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20modulatory%20effect%20of%20a%20novel%204,5-dihydroxy-3,3%C2%B4,4%C2%B4-trimethoxybibenzyl%20from%20Dendrobium%20lindleyi&rft.jtitle=PloS%20one&rft.au=Khoonrit,%20Pichayatri&rft.date=2020-09-01&rft.volume=15&rft.issue=9&rft.spage=e0238509&rft.epage=e0238509&rft.pages=e0238509-e0238509&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0238509&rft_dat=%3Cgale_plos_%3EA634174444%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c669t-8469fb3513720d01f132e1bce914038546bb7d21f5885820e790c750235433d73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2439291204&rft_id=info:pmid/32870935&rft_galeid=A634174444&rfr_iscdi=true |