Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi

Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung c...

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Bibliographic Details
Published in:PloS one 2020-09, Vol.15 (9), p.e0238509-e0238509
Main Authors: Khoonrit, Pichayatri, Mirdogan, Alp, Dehlinger, Adeline, Mekboonsonglarp, Wanwimon, Likhitwitayawuid, Kittisak, Priller, Josef, Böttcher, Chotima, Sritularak, Boonchoo
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood & organ donations
Care and treatment
Cell culture
Chemical compounds
Chemical properties
Chemokines
Chromatography
Chronic illnesses
Cytokines
Dendrobium
Health aspects
Herbal medicine
In vivo methods and tests
Inflammation
Interleukin 6
Laboratories
Lipopolysaccharides
Lung cancer
Lung diseases
Medicine and Health Sciences
Metabolites
Metastases
Metastasis
Methods
Monocytes
Orchids
Pathogens
Pharmaceutical sciences
Pharmacology
Plant extracts
Plant metabolites
Populations
Psychiatry
Research and analysis methods
Testing
Tissue culture
Tumor necrosis factor
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Summary:Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on lung cancer growth and metastasis in ex vivo human cell line models, suggesting their potential for clinical application in patients with lung cancer. However, it remains to be determined whether these therapeutic effects can be also seen in primary human cells and/or in vivo. In this study, we comparatively investigated the immune modulatory effects of bibenzyls and phenanthrenes, including a novel Dendrobium bibenzyl derivative, in primary human monocytes. All compounds were isolated and purified from a Thai orchid Dendrobium lindleyi Steud, a new source of therapeutic compounds with promising potential of tissue culture production. We detected increased frequencies of TNF- and IL-6-expressing monocytes after treatment with gigantol and cypripedin, whereas chrysotoxine and moscatilin did not alter the expression of these cytokines in monocytes. Interestingly, the new 4,5-dihydroxy-3,3',4'-trimethoxybibenzyl derivative showed dose-dependent immune modulatory effects in lipopolysaccharide (LPS)-treated CD14.sup.lo and CD14.sup.hi monocytes. Together, our findings show immune modulatory effects of the new bibenzyl derivative from Dendrobium lindleyi on different monocyte sub-populations. However, therapeutic consequences of these different monocyte populations on human diseases including cancer remain to be investigated.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0238509