Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals

Infection with parasitic helminths has been reported to improve insulin sensitivity and glucose homeostasis, lowering the risk for type 2 diabetes. However, little is known about its impact on whole-body lipid homeostasis, especially in obese individuals. For this purpose, a cross-sectional study wa...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2020-07, Vol.14 (7), p.e0008464-e0008464
Main Authors: Zinsou, Jeannot F., Janse, Jacqueline J., Honpkehedji, Yabo Y., Dejon-Agobé, Jean Claude, García-Tardón, Noemí, Hoekstra, Pytsje T., Massinga-Loembe, Marguerite, Corstjens, Paul L. A. M., van Dam, Govert J., Giera, Martin, Kremsner, Peter G., Yazdanbakhsh, Maria, Adegnika, Ayola A., Guigas, Bruno
Format: Article
Language:English
Subjects:
Adults
Antigens
Biology and Life Sciences
Blood cholesterol
Blood glucose
Body mass
Body mass index
Body size
Body weight
Cholesterol
Control
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Eggs
Funding
Glucose
Health aspects
Health risks
Hematology
High density lipoprotein
Homeostasis
Immune system
Infections
Inflammation
Insulin
Insulin resistance
Levels
Lipids
Lipoproteins
Lipoproteins (high density)
Lipoproteins (low density)
Low density lipoprotein
Medicine and Health Sciences
Metabolic syndrome
Overweight
Overweight persons
Parasites
Parasitology
Peripheral blood
Physiological aspects
Risk reduction
Schistosoma haematobium
Schistosomiasis
Serum
Supervision
Triglycerides
Tropical diseases
Urine
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Description
Summary:Infection with parasitic helminths has been reported to improve insulin sensitivity and glucose homeostasis, lowering the risk for type 2 diabetes. However, little is known about its impact on whole-body lipid homeostasis, especially in obese individuals. For this purpose, a cross-sectional study was carried out in lean and overweight/obese adults residing in the Lambaréné region of Gabon, an area endemic for Schistosoma haematobium. Helminth infection status, peripheral blood immune cell counts, and serum metabolic and lipid/lipoprotein levels were analyzed. We found that urine S. haematobium egg-positive individuals exhibited lower serum total cholesterol (TC; 4.42 vs 4.01 mmol/L, adjusted mean difference [95%CI] -0.30 [-0.68,-0.06]; P = 0.109), high-density lipoprotein (HDL)-C (1.44 vs 1.12 mmol/L, -0.24 [-0.43,-0.06]; P = 0.009) and triglyceride (TG; 0.93 vs 0.72 mmol/L, -0.20 [-0.39,-0.03]; P = 0.022) levels than egg-negative individuals. However, when stratified according to body mass index, these effects were only observed in overweight/obese infected individuals. Similarly, significant negative correlations between the intensity of infection, assessed by serum circulating anodic antigen (CAA) concentrations, and TC (r = -0.555; P
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0008464