Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion

Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0237104-e0237104
Main Authors: Akatsu, Hiroyasu, Manabe, Toshie, Kawade, Yoshihiro, Tanaka, Hajime, Kanematsu, Takayoshi, Arakawa, Kazuyuki, Masaki, Yoshiyuki, Hishida, Chie, Kanesaka, Takeshi, Ogawa, Norihiro, Hashizume, Yoshio, Tsuneyama, Koichi, Ohara, Hirotaka, Maruyama, Mitsuo, Yamamoto, Takayuki
Format: Article
Language:English
Subjects:
Albumins
Analysis
Autopsies
Autopsy
Biology and Life Sciences
Blood
Care and treatment
Composition
Deposition
Diagnostic specimens
Dietary minerals
Dosage
Drug dosages
Elderly patients
Ferritin
Food and nutrition
Geriatrics
Gerontology
Health aspects
Hepatitis
Hepcidin
Hospitals
Infusion
Interleukin 6
Intravenous administration
Iron
Iron (Nutrient)
Iron content
Laboratories
Liver
Medical education
Medical examination
Medicine and Health Sciences
Minerals
Nutrition
Older people
Parenteral nutrition
Patient outcomes
Patients
Physical Sciences
Pigments
Quality
Research and Analysis Methods
Staining
Stains & staining
Statistical analysis
Statistical methods
Studies
Supervision
Surgery
University graduates
Variables
Veins
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3
cites cdi_FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3
container_end_page e0237104
container_issue 8
container_start_page e0237104
container_title PloS one
container_volume 15
creator Akatsu, Hiroyasu
Manabe, Toshie
Kawade, Yoshihiro
Tanaka, Hajime
Kanematsu, Takayoshi
Arakawa, Kazuyuki
Masaki, Yoshiyuki
Hishida, Chie
Kanesaka, Takeshi
Ogawa, Norihiro
Hashizume, Yoshio
Tsuneyama, Koichi
Ohara, Hirotaka
Maruyama, Mitsuo
Yamamoto, Takayuki
description Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients. Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations. Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p
doi_str_mv 10.1371/journal.pone.0237104
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2430360504</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A631557020</galeid><doaj_id>oai_doaj_org_article_af67705082d54d71b0d02c99b687b94d</doaj_id><sourcerecordid>A631557020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3</originalsourceid><addsrcrecordid>eNqNk9-L1DAQx4so3rn6HwgWBNGHXSdJk7YvwnH4Y-HgwF-vIU2mu1napibtov-96W6Vq9yD9KFh8pnvZL7MJMlzAhvCcvL24EbfqWbTuw43QGMIsgfJJSkZXQsK7OGd80XyJIQDAGeFEI-TC0ZzDlCwy8RsvetSg70LdrDxaLtUjYPrg0WTNvaIPg09attiF9LauzZ1jYnBXg0WuyGkHjXao-12MXXw6oidG0Nq_UmrHkMUfZo8qlUT8Nn8XyXfPrz_ev1pfXP7cXt9dbPWOWHDuqJlhmWJjFBGgfC6EJzUXFUgWD093lCsNOQKKspJXhNjTE4KmnHFlAHNVsmLs27fuCBng4KkGQMmgEMWie2ZME4dZO9tq_wv6ZSVp4DzO6n8YHWDUtUiz2NSQQ3PYp0KDFBdlpUo8qrMTNR6N1cbqxaNxqn9ZiG6vOnsXu7cUeYZUA4kCryeBbz7MWIYZGuDxqZRHUYPT-8WAgrBIvryH_T-7mZqp2ID0X0X6-pJVF4JRjjPIQ7DKtncQ8XPYGt1nKbaxvgi4c0iITID_hx2agxBbr98_n_29vuSfXWH3aNqhn1wzTjNYViC2RnU3oXgsf5rMgE5LcMfN-S0DHJeBvYb2Fn6iw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430360504</pqid></control><display><type>article</type><title>Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Akatsu, Hiroyasu ; Manabe, Toshie ; Kawade, Yoshihiro ; Tanaka, Hajime ; Kanematsu, Takayoshi ; Arakawa, Kazuyuki ; Masaki, Yoshiyuki ; Hishida, Chie ; Kanesaka, Takeshi ; Ogawa, Norihiro ; Hashizume, Yoshio ; Tsuneyama, Koichi ; Ohara, Hirotaka ; Maruyama, Mitsuo ; Yamamoto, Takayuki</creator><contributor>Kanda, Tatsuo</contributor><creatorcontrib>Akatsu, Hiroyasu ; Manabe, Toshie ; Kawade, Yoshihiro ; Tanaka, Hajime ; Kanematsu, Takayoshi ; Arakawa, Kazuyuki ; Masaki, Yoshiyuki ; Hishida, Chie ; Kanesaka, Takeshi ; Ogawa, Norihiro ; Hashizume, Yoshio ; Tsuneyama, Koichi ; Ohara, Hirotaka ; Maruyama, Mitsuo ; Yamamoto, Takayuki ; Kanda, Tatsuo</creatorcontrib><description>Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients. Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations. Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p&lt;0.001). Additionally, the duration of TPN in the iron-positive group was significantly longer than in the iron-negative group (p = 0.038). Serum analysis revealed that unsaturated serum iron was significantly higher in the iron-negative group and that ferritin and serum iron were significantly higher in the iron-positive group. No other statistically significant differences were observed between the two groups. Chronic intravenous administration of iron was associated with iron deposition in the liver, even when given the minimum recommended dosage. In long-term TPN patients, the iron dose should therefore be carefully considered.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237104</identifier><identifier>PMID: 32750083</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Albumins ; Analysis ; Autopsies ; Autopsy ; Biology and Life Sciences ; Blood ; Care and treatment ; Composition ; Deposition ; Diagnostic specimens ; Dietary minerals ; Dosage ; Drug dosages ; Elderly patients ; Ferritin ; Food and nutrition ; Geriatrics ; Gerontology ; Health aspects ; Hepatitis ; Hepcidin ; Hospitals ; Infusion ; Interleukin 6 ; Intravenous administration ; Iron ; Iron (Nutrient) ; Iron content ; Laboratories ; Liver ; Medical education ; Medical examination ; Medicine and Health Sciences ; Minerals ; Nutrition ; Older people ; Parenteral nutrition ; Patient outcomes ; Patients ; Physical Sciences ; Pigments ; Quality ; Research and Analysis Methods ; Staining ; Stains &amp; staining ; Statistical analysis ; Statistical methods ; Studies ; Supervision ; Surgery ; University graduates ; Variables ; Veins ; Vitamins</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0237104-e0237104</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Akatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Akatsu et al 2020 Akatsu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3</citedby><cites>FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3</cites><orcidid>0000-0002-0089-6033 ; 0000-0003-0318-0441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2430360504/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2430360504?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids></links><search><contributor>Kanda, Tatsuo</contributor><creatorcontrib>Akatsu, Hiroyasu</creatorcontrib><creatorcontrib>Manabe, Toshie</creatorcontrib><creatorcontrib>Kawade, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Hajime</creatorcontrib><creatorcontrib>Kanematsu, Takayoshi</creatorcontrib><creatorcontrib>Arakawa, Kazuyuki</creatorcontrib><creatorcontrib>Masaki, Yoshiyuki</creatorcontrib><creatorcontrib>Hishida, Chie</creatorcontrib><creatorcontrib>Kanesaka, Takeshi</creatorcontrib><creatorcontrib>Ogawa, Norihiro</creatorcontrib><creatorcontrib>Hashizume, Yoshio</creatorcontrib><creatorcontrib>Tsuneyama, Koichi</creatorcontrib><creatorcontrib>Ohara, Hirotaka</creatorcontrib><creatorcontrib>Maruyama, Mitsuo</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><title>Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion</title><title>PloS one</title><description>Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients. Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations. Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p&lt;0.001). Additionally, the duration of TPN in the iron-positive group was significantly longer than in the iron-negative group (p = 0.038). Serum analysis revealed that unsaturated serum iron was significantly higher in the iron-negative group and that ferritin and serum iron were significantly higher in the iron-positive group. No other statistically significant differences were observed between the two groups. Chronic intravenous administration of iron was associated with iron deposition in the liver, even when given the minimum recommended dosage. In long-term TPN patients, the iron dose should therefore be carefully considered.</description><subject>Albumins</subject><subject>Analysis</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Care and treatment</subject><subject>Composition</subject><subject>Deposition</subject><subject>Diagnostic specimens</subject><subject>Dietary minerals</subject><subject>Dosage</subject><subject>Drug dosages</subject><subject>Elderly patients</subject><subject>Ferritin</subject><subject>Food and nutrition</subject><subject>Geriatrics</subject><subject>Gerontology</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepcidin</subject><subject>Hospitals</subject><subject>Infusion</subject><subject>Interleukin 6</subject><subject>Intravenous administration</subject><subject>Iron</subject><subject>Iron (Nutrient)</subject><subject>Iron content</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Medical education</subject><subject>Medical examination</subject><subject>Medicine and Health Sciences</subject><subject>Minerals</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Parenteral nutrition</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Pigments</subject><subject>Quality</subject><subject>Research and Analysis Methods</subject><subject>Staining</subject><subject>Stains &amp; staining</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Studies</subject><subject>Supervision</subject><subject>Surgery</subject><subject>University graduates</subject><subject>Variables</subject><subject>Veins</subject><subject>Vitamins</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-L1DAQx4so3rn6HwgWBNGHXSdJk7YvwnH4Y-HgwF-vIU2mu1napibtov-96W6Vq9yD9KFh8pnvZL7MJMlzAhvCcvL24EbfqWbTuw43QGMIsgfJJSkZXQsK7OGd80XyJIQDAGeFEI-TC0ZzDlCwy8RsvetSg70LdrDxaLtUjYPrg0WTNvaIPg09attiF9LauzZ1jYnBXg0WuyGkHjXao-12MXXw6oidG0Nq_UmrHkMUfZo8qlUT8Nn8XyXfPrz_ev1pfXP7cXt9dbPWOWHDuqJlhmWJjFBGgfC6EJzUXFUgWD093lCsNOQKKspJXhNjTE4KmnHFlAHNVsmLs27fuCBng4KkGQMmgEMWie2ZME4dZO9tq_wv6ZSVp4DzO6n8YHWDUtUiz2NSQQ3PYp0KDFBdlpUo8qrMTNR6N1cbqxaNxqn9ZiG6vOnsXu7cUeYZUA4kCryeBbz7MWIYZGuDxqZRHUYPT-8WAgrBIvryH_T-7mZqp2ID0X0X6-pJVF4JRjjPIQ7DKtncQ8XPYGt1nKbaxvgi4c0iITID_hx2agxBbr98_n_29vuSfXWH3aNqhn1wzTjNYViC2RnU3oXgsf5rMgE5LcMfN-S0DHJeBvYb2Fn6iw</recordid><startdate>20200804</startdate><enddate>20200804</enddate><creator>Akatsu, Hiroyasu</creator><creator>Manabe, Toshie</creator><creator>Kawade, Yoshihiro</creator><creator>Tanaka, Hajime</creator><creator>Kanematsu, Takayoshi</creator><creator>Arakawa, Kazuyuki</creator><creator>Masaki, Yoshiyuki</creator><creator>Hishida, Chie</creator><creator>Kanesaka, Takeshi</creator><creator>Ogawa, Norihiro</creator><creator>Hashizume, Yoshio</creator><creator>Tsuneyama, Koichi</creator><creator>Ohara, Hirotaka</creator><creator>Maruyama, Mitsuo</creator><creator>Yamamoto, Takayuki</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0089-6033</orcidid><orcidid>https://orcid.org/0000-0003-0318-0441</orcidid></search><sort><creationdate>20200804</creationdate><title>Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion</title><author>Akatsu, Hiroyasu ; Manabe, Toshie ; Kawade, Yoshihiro ; Tanaka, Hajime ; Kanematsu, Takayoshi ; Arakawa, Kazuyuki ; Masaki, Yoshiyuki ; Hishida, Chie ; Kanesaka, Takeshi ; Ogawa, Norihiro ; Hashizume, Yoshio ; Tsuneyama, Koichi ; Ohara, Hirotaka ; Maruyama, Mitsuo ; Yamamoto, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Albumins</topic><topic>Analysis</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Care and treatment</topic><topic>Composition</topic><topic>Deposition</topic><topic>Diagnostic specimens</topic><topic>Dietary minerals</topic><topic>Dosage</topic><topic>Drug dosages</topic><topic>Elderly patients</topic><topic>Ferritin</topic><topic>Food and nutrition</topic><topic>Geriatrics</topic><topic>Gerontology</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Hepcidin</topic><topic>Hospitals</topic><topic>Infusion</topic><topic>Interleukin 6</topic><topic>Intravenous administration</topic><topic>Iron</topic><topic>Iron (Nutrient)</topic><topic>Iron content</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Medical education</topic><topic>Medical examination</topic><topic>Medicine and Health Sciences</topic><topic>Minerals</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Parenteral nutrition</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Pigments</topic><topic>Quality</topic><topic>Research and Analysis Methods</topic><topic>Staining</topic><topic>Stains &amp; staining</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Studies</topic><topic>Supervision</topic><topic>Surgery</topic><topic>University graduates</topic><topic>Variables</topic><topic>Veins</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akatsu, Hiroyasu</creatorcontrib><creatorcontrib>Manabe, Toshie</creatorcontrib><creatorcontrib>Kawade, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Hajime</creatorcontrib><creatorcontrib>Kanematsu, Takayoshi</creatorcontrib><creatorcontrib>Arakawa, Kazuyuki</creatorcontrib><creatorcontrib>Masaki, Yoshiyuki</creatorcontrib><creatorcontrib>Hishida, Chie</creatorcontrib><creatorcontrib>Kanesaka, Takeshi</creatorcontrib><creatorcontrib>Ogawa, Norihiro</creatorcontrib><creatorcontrib>Hashizume, Yoshio</creatorcontrib><creatorcontrib>Tsuneyama, Koichi</creatorcontrib><creatorcontrib>Ohara, Hirotaka</creatorcontrib><creatorcontrib>Maruyama, Mitsuo</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akatsu, Hiroyasu</au><au>Manabe, Toshie</au><au>Kawade, Yoshihiro</au><au>Tanaka, Hajime</au><au>Kanematsu, Takayoshi</au><au>Arakawa, Kazuyuki</au><au>Masaki, Yoshiyuki</au><au>Hishida, Chie</au><au>Kanesaka, Takeshi</au><au>Ogawa, Norihiro</au><au>Hashizume, Yoshio</au><au>Tsuneyama, Koichi</au><au>Ohara, Hirotaka</au><au>Maruyama, Mitsuo</au><au>Yamamoto, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion</atitle><jtitle>PloS one</jtitle><date>2020-08-04</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0237104</spage><epage>e0237104</epage><pages>e0237104-e0237104</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Undefined-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><abstract>Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients. Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations. Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p&lt;0.001). Additionally, the duration of TPN in the iron-positive group was significantly longer than in the iron-negative group (p = 0.038). Serum analysis revealed that unsaturated serum iron was significantly higher in the iron-negative group and that ferritin and serum iron were significantly higher in the iron-positive group. No other statistically significant differences were observed between the two groups. Chronic intravenous administration of iron was associated with iron deposition in the liver, even when given the minimum recommended dosage. In long-term TPN patients, the iron dose should therefore be carefully considered.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32750083</pmid><doi>10.1371/journal.pone.0237104</doi><tpages>e0237104</tpages><orcidid>https://orcid.org/0000-0002-0089-6033</orcidid><orcidid>https://orcid.org/0000-0003-0318-0441</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2020-08, Vol.15 (8), p.e0237104-e0237104
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2430360504
source Publicly Available Content Database; PubMed Central
subjects Albumins
Analysis
Autopsies
Autopsy
Biology and Life Sciences
Blood
Care and treatment
Composition
Deposition
Diagnostic specimens
Dietary minerals
Dosage
Drug dosages
Elderly patients
Ferritin
Food and nutrition
Geriatrics
Gerontology
Health aspects
Hepatitis
Hepcidin
Hospitals
Infusion
Interleukin 6
Intravenous administration
Iron
Iron (Nutrient)
Iron content
Laboratories
Liver
Medical education
Medical examination
Medicine and Health Sciences
Minerals
Nutrition
Older people
Parenteral nutrition
Patient outcomes
Patients
Physical Sciences
Pigments
Quality
Research and Analysis Methods
Staining
Stains & staining
Statistical analysis
Statistical methods
Studies
Supervision
Surgery
University graduates
Variables
Veins
Vitamins
title Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T04%3A47%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Iron%20deposition%20in%20autopsied%20liver%20specimens%20from%20older%20patients%20receiving%20intravenous%20iron%20infusion&rft.jtitle=PloS%20one&rft.au=Akatsu,%20Hiroyasu&rft.date=2020-08-04&rft.volume=15&rft.issue=8&rft.spage=e0237104&rft.epage=e0237104&rft.pages=e0237104-e0237104&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0237104&rft_dat=%3Cgale_plos_%3EA631557020%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c713t-b294e99e31232015f8651f5ab063f0053d2ebc07a0b2517f1ddd718245a3ad0c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2430360504&rft_id=info:pmid/32750083&rft_galeid=A631557020&rfr_iscdi=true