Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion

Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of...

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Bibliographic Details
Published in:PloS one 2020-08, Vol.15 (8), p.e0237104-e0237104
Main Authors: Akatsu, Hiroyasu, Manabe, Toshie, Kawade, Yoshihiro, Tanaka, Hajime, Kanematsu, Takayoshi, Arakawa, Kazuyuki, Masaki, Yoshiyuki, Hishida, Chie, Kanesaka, Takeshi, Ogawa, Norihiro, Hashizume, Yoshio, Tsuneyama, Koichi, Ohara, Hirotaka, Maruyama, Mitsuo, Yamamoto, Takayuki
Format: Article
Language:English
Subjects:
Albumins
Analysis
Autopsies
Autopsy
Biology and Life Sciences
Blood
Care and treatment
Composition
Deposition
Diagnostic specimens
Dietary minerals
Dosage
Drug dosages
Elderly patients
Ferritin
Food and nutrition
Geriatrics
Gerontology
Health aspects
Hepatitis
Hepcidin
Hospitals
Infusion
Interleukin 6
Intravenous administration
Iron
Iron (Nutrient)
Iron content
Laboratories
Liver
Medical education
Medical examination
Medicine and Health Sciences
Minerals
Nutrition
Older people
Parenteral nutrition
Patient outcomes
Patients
Physical Sciences
Pigments
Quality
Research and Analysis Methods
Staining
Stains & staining
Statistical analysis
Statistical methods
Studies
Supervision
Surgery
University graduates
Variables
Veins
Vitamins
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Summary:Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients. Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations. Iron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0237104