Evaluation of oxidative stress effects on different macromolecules in adult growth hormone deficiency

Adult growth hormone deficiency (GHD) is being increasingly recognized to cause premature mortality exacerbated by oxidative stress. A case-control observational study has been performed with the primary objective of evaluating new parameters of oxidative stress and macromolecular damage in adult GH...

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Bibliographic Details
Published in:PloS one 2020-07, Vol.15 (7), p.e0236357-e0236357
Main Authors: Mancini, Antonio, Bruno, Carmine, Vergani, Edoardo, Guidi, Francesco, Angelini, Flavia, Meucci, Elisabetta, Silvestrini, Andrea
Format: Article
Language:English
Subjects:
8-Hydroxy-2'-Deoxyguanosine - urine
Adult
Adults
Anticoagulants
Antioxidants
Antioxidants - analysis
Apoptosis
Arginine
Arnold-Chiari Malformation - blood
Arnold-Chiari Malformation - complications
Arnold-Chiari Malformation - metabolism
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Biomarkers - urine
Case-Control Studies
Complications
Congenital diseases
Deoxyguanosine
Deoxyribonucleic acid
DNA
DNA damage
Empty Sella Syndrome - blood
Empty Sella Syndrome - complications
Empty Sella Syndrome - metabolism
Evaluation
Female
Growth hormone
Growth hormone-releasing hormone
Growth hormones
Health aspects
Human Growth Hormone - deficiency
Humans
Hypertension
Hypopituitarism - blood
Hypopituitarism - etiology
Hypopituitarism - metabolism
Hypopituitarism - urine
Immunoassay
Insulin resistance
Insulin-like growth factors
Lag time
Lipid Peroxidation
Lipids
Lysine
Lysine - blood
Macromolecules
Male
Medicine and Health Sciences
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Metabolic Syndrome - metabolism
Metabolic Syndrome - urine
Metabolism
Middle Aged
Observations
Oxidative stress
Oxidative Stress - physiology
Parameters
Proteins
Serum levels
Software
Somatotropin
Supervision
Tryptophan - analogs & derivatives
Tryptophan - blood
Tyrosine - analogs & derivatives
Tyrosine - urine
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Summary:Adult growth hormone deficiency (GHD) is being increasingly recognized to cause premature mortality exacerbated by oxidative stress. A case-control observational study has been performed with the primary objective of evaluating new parameters of oxidative stress and macromolecular damage in adult GHD subjects: serum nitrotryptophan; Total Antioxidant Capacity expressed as LAG time; urinary hexanoil-lysine; urinary dityrosine and urinary 8-OH-deoxyguanosine. GHD was diagnosed using Growth Hormone-Releasing Hormone 50μg iv+arginine 0,5 g/Kg test, with a peak GH response
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236357