Effect of experimental, morphological and mechanical factors on the murine spinal cord subjected to transverse contusion: A finite element study

Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal...

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Bibliographic Details
Published in:PloS one 2020-05, Vol.15 (5), p.e0232975-e0232975
Main Authors: Fournely, Marion, Petit, Yvan, Wagnac, Eric, Evin, Morgane, Arnoux, Pierre-Jean
Format: Article
Language:English
Subjects:
Animal experimentation
Animal models
Bioengineering
Biology and Life Sciences
Biomechanics
Characterization
Contusions
Deformation effects
Finite element method
Injuries
Laboratories
Life Sciences
Material properties
Mathematical analysis
Mathematical models
Mechanical engineering
Mechanical properties
Medicine and Health Sciences
Methods
Morphology
Pareto analysis
Physical Sciences
Spinal cord injuries
Strain analysis
Strain distribution
Substantia alba
Tissues
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Summary:Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal cord in order to investigate the effect of morphological, experimental and mechanical factors on the spinal cord mechanical behavior subjected to transverse contusion. The overall mechanical behavior of the model was validated with experimental data of unilateral cervical contusion in mice. The effects of the spinal cord material properties, diameter and curvature, and of the impactor position and inclination on the strain distribution were investigated in 8 spinal cord anatomical regions of interest for 98 configurations of the model. Pareto analysis revealed that the material properties had a significant effect (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0232975