Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

Advancements in the field of synthetic biology have been possible due to the development of genetic tools that are able to regulate gene expression. However, the current toolbox of gene regulatory tools for eukaryotic systems have been outpaced by those developed for simple, single-celled systems. H...

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Bibliographic Details

Published in:	PloS one 2020-04, Vol.15 (4), p.e0232046-e0232046
Main Authors:	Jacobsen, Thomas, Yi, Gloria, Al Asafen, Hadel, Jermusyk, Ashley A, Beisel, Chase L, Reeves, Gregory T
Format:	Article
Language:	eng
Subjects:	3' Untranslated regions Animals Bacteria Binding sites Biology and Life Sciences Drosophila - genetics Embryos Engineering Engineers Eukaryota - genetics Eukaryota - metabolism Eukaryotic Cells - metabolism Fruit flies Gene expression Gene Expression - genetics Gene Expression - physiology Gene Expression Regulation - genetics Gene Expression Regulation - physiology Genetic Engineering - methods Insects Mammalian cells Nucleic Acid Conformation Physical Sciences Plasmids Proof of Concept Study Protein synthesis Proteins Research and Analysis Methods Ribozymes RNA, Catalytic - genetics RNA, Catalytic - physiology RNA, Messenger - metabolism Synthetic Biology - methods Transcription factors
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