Epidemiology of Staphylococcus aureus in neonates on admission to a Chinese neonatal intensive care unit

Little is known about the molecular epidemiology of Staphylococcus aureus in Chinese neonatal intensive care units (NICUs). We describe the molecular epidemiology of S. aureus isolated from neonates on admission to Beijing Children's Hospital. From May 2015-March 2016, nasal swabs were obtained...

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Bibliographic Details
Published in:PloS one 2020-02, Vol.15 (2), p.e0211845-e0211845
Main Authors: Geng, Wenjing, Qi, Yujie, Li, Wenting, McConville, Thomas H, Hill-Ricciuti, Alexandra, Grohs, Emily C, Saiman, Lisa, Uhlemann, Anne-Catrin
Format: Article
Language:English
Subjects:
Age Factors
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibiotics
Biology and life sciences
Birth Weight
Children & youth
Childrens health
China - epidemiology
Colonization
Congenital diseases
Cytotoxicity
Decolonization
Disease prevention
Drug resistance
Drug Resistance, Multiple, Bacterial
Epidemiology
Female
Guardians
Health risks
Hospitals
Humans
Infant, Low Birth Weight
Infant, Newborn
Infants
Infections
Infectious diseases
Intensive care
Intensive care units
Intensive Care Units, Neonatal - statistics & numerical data
Laboratories
Male
Mass Screening
Medical records
Medicine and health sciences
Methicillin
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
Molecular Epidemiology
Multilocus Sequence Typing - statistics & numerical data
Neonates
Newborn babies
Oxacillin
Pediatrics
Penicillin
People and Places
Protein A
Research and Analysis Methods
Risk analysis
Risk Factors
Risk groups
Serotyping - statistics & numerical data
Sex Factors
Staphylococcal Infections - diagnosis
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal Protein A - isolation & purification
Staphylococcus aureus
Staphylococcus infections
Studies
Surveillance
Toxicity
Vagina
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Summary:Little is known about the molecular epidemiology of Staphylococcus aureus in Chinese neonatal intensive care units (NICUs). We describe the molecular epidemiology of S. aureus isolated from neonates on admission to Beijing Children's Hospital. From May 2015-March 2016, nasal swabs were obtained on admission from 536 neonates. Cultures were also obtained from body sites with suspected infections. S. aureus isolates were characterized by staphylococcal chromosomal cassette (SCCmec) type, staphylococcal protein A (spa) type, multilocus sequence type (MLST), sasX gene, antimicrobial susceptibility and cytotoxicity. Logistic regression assessed risk factors for colonization. Overall, 92 (17%) infants were colonized with S. aureus and 20 (3.7%) were diagnosed with culture-positive S. aureus infection. Of the colonized infants, 70% (64/92) harbored methicillin-susceptible S. aureus (MSSA), 30% (28/92) harbored methicillin-resistant S. aureus (MRSA) while 70% (14/20) of infected infants were culture-positive for MRSA, 30% (6/20) were culture-positive for MSSA. Risk factors for colonization included female sex, age 7-28 days, higher birthweight (3270 IQR [2020-3655] grams) and vaginal delivery (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0211845