Meta-analysis of the radiological and clinical features of Usual Interstitial Pneumonia (UIP) and Nonspecific Interstitial Pneumonia (NSIP)

To conduct a meta-analysis to determine specific computed tomography (CT) patterns and clinical features that discriminate between nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). The PubMed/Medline and Embase databases were searched for studies describing the radiol...

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Bibliographic Details
Published in:PloS one 2020-01, Vol.15 (1), p.e0226084
Main Authors: Ebner, Lukas, Christodoulidis, Stergios, Stathopoulou, Thomai, Geiser, Thomas, Stalder, Odile, Limacher, Andreas, Heverhagen, Johannes T, Mougiakakou, Stavroula G, Christe, Andreas
Format: Article
Language:English
Subjects:
Age Factors
Binary data
Biology and Life Sciences
Biomedical engineering
Biopsy
Computed tomography
Demographics
Demography
Diagnosis
Engineering research
Geriatrics
Hospitals
Humans
Idiopathic Pulmonary Fibrosis - diagnostic imaging
Idiopathic Pulmonary Fibrosis - epidemiology
Idiopathic Pulmonary Fibrosis - pathology
Lung - diagnostic imaging
Lung - physiology
Lung diseases
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - epidemiology
Lung Diseases, Interstitial - pathology
Males
Medical diagnosis
Medical prognosis
Medicine and Health Sciences
Meta-analysis
Patients
Pediatrics
People and Places
Physical Sciences
Pneumonia
Prevalence
Preventive medicine
Pulmonary fibrosis
Radiology
Research and Analysis Methods
Sex Factors
Smoking
Social Sciences
Society
Systematic review
Tomography, X-Ray Computed
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Summary:To conduct a meta-analysis to determine specific computed tomography (CT) patterns and clinical features that discriminate between nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). The PubMed/Medline and Embase databases were searched for studies describing the radiological patterns of UIP and NSIP in chest CT images. Only studies involving histologically confirmed diagnoses and a consensus diagnosis by an interstitial lung disease (ILD) board were included in this analysis. The radiological patterns and patient demographics were extracted from suitable articles. We used random-effects meta-analysis by DerSimonian & Laird and calculated pooled odds ratios for binary data and pooled mean differences for continuous data. Of the 794 search results, 33 articles describing 2,318 patients met the inclusion criteria. Twelve of these studies included both NSIP (338 patients) and UIP (447 patients). NSIP-patients were significantly younger (NSIP: median age 54.8 years, UIP: 59.7 years; mean difference (MD) -4.4; p = 0.001; 95% CI: -6.97 to -1.77), less often male (NSIP: median 52.8%, UIP: 73.6%; pooled odds ratio (OR) 0.32; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0226084