Cohort Profile: The Dutch Perined-Lifelines birth cohort

Maternal nutrition status (e.g. dietary/nutrient intake) during pregnancy has been associated with pregnancy outcomes including birth weight, infant survival and metabolic health of the offspring during later life. During the past few years, maternal dietary intake, at least three months before conc...

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Bibliographic Details
Published in:PloS one 2019-12, Vol.14 (12), p.e0225973-e0225973
Main Authors: Salavati, Nastaran, Bakker, Marian K, van der Beek, Eline M, Erwich, JanJaap H M
Format: Article
Language:English
Subjects:
Adult
Biology and Life Sciences
Birth weight
Cohort analysis
Cohort Studies
Data collection
Diabetes
Diet
Dietary intake
Energy Intake
Epidemiology
Female
Food groups
Food intake
Gynecology
Health risk assessment
Human nutrition
Humans
Iodine
Longitudinal studies
Maternal Nutritional Physiological Phenomena
Medicine and Health Sciences
Netherlands - epidemiology
Nutrient status
Nutrients
Nutrition
Nutrition research
Nutritional Status
Obstetrics
Offspring
People and Places
Physical Sciences
Population
Population studies
Pregnancy
Pregnancy Outcome
Premature birth
Public Health Surveillance
Questionnaires
Registries
Research and Analysis Methods
Trusted third parties
Women's Health
Womens health
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Summary:Maternal nutrition status (e.g. dietary/nutrient intake) during pregnancy has been associated with pregnancy outcomes including birth weight, infant survival and metabolic health of the offspring during later life. During the past few years, maternal dietary intake, at least three months before conception, has been shown to affect pregnancy outcomes also. However, literature investigating this link is still scarce. The studies that have looked at preconception dietary intake in relation to pregnancy outcome were either animal studies, had small sample sizes or focused on only selected macronutrient intake rather than complete (macro)nutrient composition or dietary intakes (e.g. food groups). Therefore, we aim to investigate the association between preconception diet and pregnancy outcomes in a linked birth cohort. The main objective of this manuscript is to describe the methodology of establishing this birth cohort and to describe both the characteristics of the study population included as well as the representativeness in terms of dietary intake. We created the birth cohort by linking two existing databases; a large population-based cohort study in the Netherlands (The Lifelines Cohort study) and the Dutch national birth registry (Perined), through a 'trusted third party'. The birth cohort contains information on maternal dietary intake during preconception as well as pregnancy outcomes. In the Lifelines Cohort study, 3,418 pregnancies were available for linking with Perined. In total, 2,368 pregnancies (86.9%) were linked with Perined, resulting in the birth cohort. With this linked cohort we are able to provide insights on the associations between dietary intake before conception and pregnancy outcomes. Such data could potentially improve nutritional care for women of childbearing age. Lifestyle changes in the period preceding pregnancy may be most effective in improving pregnancy outcomes. A focus on this window of opportunity may provide both sufficient time, as well as a period when women are potentially motivated to adopt health optimizing behaviours.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0225973