Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer

Previous studies have documented an intrinsic association between breast cancer (BC) and thyroid cancer (TC), but the clinical relevance of this relationship is not well defined. In the present study, we specifically investigated the impact of a history of TC on clinical outcomes of BC. We performed...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-10, Vol.14 (10), p.e0221093-e0221093
Main Authors: Cheng, Weiwei, Shen, Xiaopei, Xing, Mingzhao
Format: Article
Language:English
Subjects:
Age
Aged
Biology and Life Sciences
Biomarkers
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Clinical outcomes
Comparative analysis
Databases, Factual
Diabetes
Endocrinology
Engineering and Technology
Epidemiology
Estrogens
Female
Follow-Up Studies
Health risks
Histology
Humans
Laboratories
Mammography
Medical diagnosis
Medical prognosis
Medicine
Medicine and Health Sciences
Menopause
Metabolism
Metastases
Middle Aged
Mortality
Mutation
Neoplasm Metastasis
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - metabolism
Neoplasms, Second Primary - mortality
Neoplasms, Second Primary - pathology
Patients
Population studies
Progesterone
Registries
Retrospective Studies
Social factors
Socioeconomic data
Socioeconomic factors
Socioeconomics
Surveillance
Systematic review
Thyroid
Thyroid cancer
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Tumors
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have documented an intrinsic association between breast cancer (BC) and thyroid cancer (TC), but the clinical relevance of this relationship is not well defined. In the present study, we specifically investigated the impact of a history of TC on clinical outcomes of BC. We performed a population-based comparative analysis of tumor behaviors and BC-specific mortalities in 427,893 female patients with BC in the USA Surveillance, Epidemiology and End Results 9 database (1973-2013). In this cohort of subjects, 2,569 patients also had a history of differentiated TC (BC/TC), including BC diagnosed before TC (BC-1st) and BC diagnosed after TC (TC-1st), with the median follow-up time of 81 (IQR, 33-160) months. We found that, compared with matched BC-only patients, less aggressive BC tumor behaviors occurred in BC/TC patients, as exemplified by a distant metastasis rate of 7.0% in the former versus 3.3% in the latter (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221093