Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide...

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Bibliographic Details
Published in:PLoS genetics 2019-09, Vol.15 (9), p.e1008208-e1008208
Main Authors: Yee, Sook Wah, Stecula, Adrian, Chien, Huan-Chieh, Zou, Ling, Feofanova, Elena V, van Borselen, Marjolein, Cheung, Kit Wun Kathy, Yousri, Noha A, Suhre, Karsten, Kinchen, Jason M, Boerwinkle, Eric, Irannejad, Roshanak, Yu, Bing, Giacomini, Kathleen M
Format: Article
Language:English
Subjects:
Acne
Amino acids
Androsterone - analogs & derivatives
Androsterone - genetics
Androsterone - metabolism
Animals
Anions
Bile acids
Bioengineering
Biological Transport
Biology and Life Sciences
Cardiovascular diseases
Genes
Genetic diversity
Genetic variation
Genetics
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Genomics
Health
HEK293 Cells
Homeostasis
Hormones
Humans
Identification
Ligands
Medicine
Medicine and Health Sciences
Menopause
Metabolism
Metabolites
Metabolomics
Metabolomics - methods
Models, Molecular
Observations
Organic Cation Transport Proteins - chemistry
Organic Cation Transport Proteins - genetics
Organic Cation Transport Proteins - metabolism
Phylogenetics
Phylogeny
Physical Sciences
Physiological aspects
Physiology
Polymorphism, Single Nucleotide
Proteins
Reabsorption
Single-nucleotide polymorphism
Steroid hormones
Steroids - metabolism
Surface active agents
Symporters - chemistry
Symporters - genetics
Symporters - metabolism
Transport proteins
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Description
Summary:Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1008208