Association between alcohol use and inflammatory biomarkers over time among younger adults with HIV-The Russia ARCH Observational Study

Biomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people with HIV. The objective of the Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study was to evaluate the as...

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Published in:PloS one 2019-08, Vol.14 (8), p.e0219710-e0219710
Main Authors: So-Armah, Kaku A, Cheng, Debbie M, Freiberg, Matthew S, Gnatienko, Natalia, Patts, Gregory, Ma, Yicheng, White, Laura, Blokhina, Elena, Lioznov, Dmitry, Doyle, Margaret F, Tracy, Russell P, Chichetto, Natalie, Bridden, Carly, Bryant, Kendall, Krupitsky, Evgeny, Samet, Jeffrey H
Format: Article
Language:English
Subjects:
Abuse
Acquired immune deficiency syndrome
Adult
Adults
AIDS
Alcohol abuse
Alcohol Drinking - blood
Alcohol Drinking - immunology
Alcohol use
Alcoholism
Alcohols
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Arches
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - blood
CD14 antigen
Cell activation
Coagulation
Cohort Studies
Comorbidity
Demographics
Demography
Dimers
Drinking (Alcoholic beverages)
Drinking behavior
Drug abuse
EDTA
Female
Fibrin Fibrinogen Degradation Products - metabolism
Health aspects
Health risks
Hepatitis
Hepatitis C
Highly active antiretroviral therapy
HIV
HIV Infections - blood
HIV Infections - immunology
HIV patients
Human immunodeficiency virus
Humans
Inflammation
Inflammation Mediators - blood
Interleukin 6
Interleukin-6 - blood
Interleukins
Linear Models
Lipopolysaccharide Receptors - blood
Longitudinal Studies
Male
Medical diagnosis
Medicine and Health Sciences
Monocytes
Mortality
Observational studies
Patient outcomes
Ribonucleic acid
RNA
Russia
Young adults
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Summary:Biomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people with HIV. The objective of the Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study was to evaluate the association between heavy alcohol use and inflammatory biomarkers over time. The study sought antiretroviral therapy naive participants with HIV (n = 350) and assessed them at baseline, 12 and 24 months. Linear mixed effects models were used to determine whether heavy drinking (self-report augmented by phosphatidylethanol [PEth], an alcohol biomarker) was longitudinally associated with IL-6, sCD14 and D-dimer adjusting for potential confounders (e.g., demographics, HIV factors, comorbid conditions). Participants' baseline characteristics were as follows: 71% male; mean age of 34 years; 87% self-reported hepatitis C; and 86% current smokers. Mean log10 (HIV RNA) was 4.3 copies/mL. Heavy alcohol use, based on National Institute of Alcohol Abuse and Alcoholism risky drinking criteria and PEth (versus non-heavy alcohol use) was associated with higher sCD14 (adjusted mean difference 125 ng/mL [95% CI: 42, 209]), IL-6 (ratio of means 1.35 [95% CI: 1.17, 1.55] pg/mL), and D-dimer (ratio of means 1.20 [95% CI: 1.06, 1.37] ug/mL) across the two-year follow-up. Among HIV+ adults, current heavy alcohol use is associated with higher sCD14, IL-6 and D-dimer over time. Since these biomarkers are associated with mortality, interventions to mitigate effects of heavy drinking on these immune processes merit consideration.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0219710