The prognostic value of NIRS in preterm infants with (suspected) late-onset sepsis in relation to long term outcome: A pilot study

Late-onset sepsis is frequently seen in preterm infants and is associated with poor neurodevelopmental outcome. White matter damage is proposed as substrate of poor outcome, with contributing factors as regional hypoxia and effects of cytokines on oligodendrocytes. We investigated the relation betwe...

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Bibliographic Details
Published in:PloS one 2019-07, Vol.14 (7), p.e0220044-e0220044
Main Authors: Zonnenberg, Inge A, Dijk, Jennifer van, Dungen, Frank A M van den, Vermeulen, R Jeroen, Weissenbruch, Mirjam M van
Format: Article
Language:English
Subjects:
Age
Analysis
Biology and Life Sciences
Birth weight
Blood culture
Blood pressure
Blood tests
Child Development
Children & youth
Coagulase
Cognitive ability
Cytokines
Developmental Disabilities - epidemiology
Female
Gestational age
Health aspects
Hospitals
Humans
Hypoxia
Infant development
Infant, Newborn
Infant, Premature
Infants
Infection
Intensive care
Long term
Male
Medical prognosis
Medicine and Health Sciences
Near-infrared spectroscopy
Neonatal Sepsis - diagnostic imaging
Neonatal Sepsis - epidemiology
Neonatal Sepsis - microbiology
Neurodegenerative diseases
Neurodevelopment
Neurology
Newborn babies
Nosocomial infections
Oligodendrocytes
Oxygenation
Perfusion
Physical Sciences
Pilot Projects
Predictive Value of Tests
Premature babies
Premature infants
Research and Analysis Methods
Sensors
Sepsis
Spectroscopy, Near-Infrared - methods
Spectroscopy, Near-Infrared - standards
Spectrum analysis
Staphylococcal Infections - diagnostic imaging
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Studies
Substantia alba
Substrates
Treatment outcome
Ultrasonic imaging
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Description
Summary:Late-onset sepsis is frequently seen in preterm infants and is associated with poor neurodevelopmental outcome. White matter damage is proposed as substrate of poor outcome, with contributing factors as regional hypoxia and effects of cytokines on oligodendrocytes. We investigated the relation between cerebral oxygenation during (suspected) late-onset sepsis and neurodevelopmental outcome. Prospective cohort study, including preterm infants (gestational age
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0220044