Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

The role of host genetic variation in the development of complicated Staphylococcus aureus bacteremia (SAB) is poorly understood. We used whole exome sequencing (WES) to examine the cumulative effect of coding variants in each gene on risk of complicated SAB in a discovery sample of 168 SAB cases (8...

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Published in:PLoS genetics 2018-10, Vol.14 (10), p.e1007667-e1007667
Main Authors: Scott, William K, Medie, Felix Mba, Ruffin, Felicia, Sharma-Kuinkel, Batu K, Cyr, Derek D, Guo, Shengru, Dykxhoorn, Derek M, Skov, Robert L, Bruun, Niels E, Dahl, Anders, Lerche, Christian J, Petersen, Andreas, Larsen, Anders Rhod, Lauridsen, Trine Kiilerich, Johansen, Helle Krogh, Ullum, Henrik, Sørensen, Erik, Hassager, Christian, Bundgaard, Henning, Schønheyder, Henrik C, Torp-Pedersen, Christian, Østergaard, Louise Bruun, Arpi, Magnus, Rosenvinge, Flemming, Erikstrup, Lise T, Chehri, Mahtab, Søgaard, Peter, Andersen, Paal S, Fowler, Jr, Vance G
Format: Article
Language:English
Subjects:
Bacteremia
Bacteria
Bioinformatics
Biology and Life Sciences
Cardiology
Cell activation
Clinical medicine
CRISPR
DNA microarrays
Endocarditis
Fungi
Gene expression
Genetic diversity
Genetics
Genome editing
Genomes
Genomics
Glutamine
Hospitals
Infections
Infectious diseases
Interleukin 1
Macrophages
Medicine
Medicine and Health Sciences
Nitric oxide
Parasites
Physical Sciences
Replication
Research and Analysis Methods
Staphylococcus aureus
Supervision
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Summary:The role of host genetic variation in the development of complicated Staphylococcus aureus bacteremia (SAB) is poorly understood. We used whole exome sequencing (WES) to examine the cumulative effect of coding variants in each gene on risk of complicated SAB in a discovery sample of 168 SAB cases (84 complicated and 84 uncomplicated, frequency matched by age, sex, and bacterial clonal complex [CC]), and then evaluated the most significantly associated genes in a replication sample of 240 SAB cases (122 complicated and 118 uncomplicated, frequency matched for age, sex, and CC) using targeted sequence capture. In the discovery sample, gene-based analysis using the SKAT-O program identified 334 genes associated with complicated SAB at p
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1007667