Influenza vaccination and secondary prevention of cardiovascular disease among Taiwanese elders-A propensity score-matched follow-up study

The present study aimed to evaluate the association between influenza vaccination and the secondary prevention of cardiovascular disease (CVD) among elderly persons. This retrospective cohort study used the Geriatric Dataset of Taiwan's National Health Insurance Research Database (2000-2013). P...

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Bibliographic Details
Published in:PloS one 2019-07, Vol.14 (7), p.e0219172-e0219172
Main Authors: Wu, Hao-Hsin, Chang, Yea-Yuan, Kuo, Shu-Chen, Chen, Yung-Tai
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biology and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Cardiovascular Diseases - therapy
Cause of Death
Clopidogrel
Confidence intervals
Congestive heart failure
Death
Elderly patients
Female
Follow-Up Studies
Geriatrics
Health
Health aspects
Health risk assessment
Heart attack
Heart attacks
Heart failure
Hospital admission and discharge
Hospitalization - statistics & numerical data
Humans
Incidence
Influenza
Influenza vaccines
Influenza Vaccines - administration & dosage
Influenza, Human - complications
Influenza, Human - prevention & control
Insurance
Kaplan-Meier Estimate
Male
Medicine and Health Sciences
Mortality
Myocardial infarction
National health insurance
Older people
Online databases
People and Places
Prevention
Propensity Score
Recurrence
Retrospective Studies
Risk analysis
Risk factors
Risk management
Secondary Prevention - methods
Socioeconomic factors
Studies
Subgroups
Taiwan - epidemiology
Vaccination
Vaccination - methods
Vaccines
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Summary:The present study aimed to evaluate the association between influenza vaccination and the secondary prevention of cardiovascular disease (CVD) among elderly persons. This retrospective cohort study used the Geriatric Dataset of Taiwan's National Health Insurance Research Database (2000-2013). Patients aged ≥ 65 years who had been hospitalized for the first episodes of myocardial infarction were eligible. The vaccinated cohort comprised patients who received one dose of influenza vaccine within 180 days after discharge. The unvaccinated cohort included those who did not receive influenza vaccination and was propensity score-matched (1:1) for known CVD risk factors. All-cause death, acute myocardial infarction or cardiovascular death, and hospitalization for heart failure were assessed 1 year after the 181st day after hospital discharge. Compared with the matched cohort (n = 4,350), the vaccinated cohort (n = 4,350) had significantly lower incidences of all-cause death (hazard ratios [HR] 0.82, 95% CI [confidence interval] 0.73-0.92), myocardial infarction or cardiovascular death (HR 0.84, 95% CI 0.74-0.96), and hospitalization for heart failure (HR 0.83, 95% CI 0.74-0.92). The association between influenza vaccination and reduction of CVDs was similar across different subgroups. Cumulative incidence curves of the CVDs of interest for the two cohorts separated within the initial 3 months of follow-up (P < 0.05). Influenza vaccination was associated with a reduced risk of CVD in the elderly population with previous myocardial infarction.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0219172