Exercise capacity in patients with cystic fibrosis vs. non-cystic fibrosis bronchiectasis

Bronchiectasis is associated with morbidity, low exercise capacity and poor quality of life. There is a paucity of data on exercise capacity using cardiopulmonary exercise test (CPET) in non-cystic fibrosis (CF) bronchiectasis. Our aim was to compare exercise capacity using CPET in CF and non-CF bro...

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Published in:PloS one 2019-06, Vol.14 (6), p.e0217491-e0217491
Main Authors: Bar-Yoseph, Ronen, Ilivitzki, Anat, Cooper, Dan M, Gur, Michal, Mainzer, Gur, Hakim, Fahed, Livnat, Galit, Schnapp, Zeev, Shalloufeh, George, Zucker-Toledano, Merav, Subar, Yael, Bentur, Lea
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Biology and Life Sciences
Body mass index
Breathing
Bronchiectasis
Bronchiectasis - metabolism
Bronchiectasis - physiopathology
Cardiology
CAT scans
Comparative analysis
Computed tomography
Control methods
Correlation analysis
Cross-Sectional Studies
Cystic fibrosis
Cystic Fibrosis - metabolism
Cystic Fibrosis - physiopathology
Diagnostic imaging
Etiology
Etiology (Medicine)
Exercise
Exercise - physiology
Exercise Test - methods
Exercise tests
Exercise Tolerance - physiology
Female
Fibrosis
Hospitals
Humans
Longitudinal studies
Lung diseases
Male
Medical schools
Medicine
Medicine and Health Sciences
Morbidity
Mortality
Oxygen
Oxygen - metabolism
Oxygen Consumption - physiology
Oxygen content
Oxygen uptake
Parameters
Patient outcomes
Patients
Pediatrics
Physical fitness
Physical Sciences
Prospective Studies
Quality of Life
Research and Analysis Methods
Respiration
Retrospective Studies
Tomography
Young Adult
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Summary:Bronchiectasis is associated with morbidity, low exercise capacity and poor quality of life. There is a paucity of data on exercise capacity using cardiopulmonary exercise test (CPET) in non-cystic fibrosis (CF) bronchiectasis. Our aim was to compare exercise capacity using CPET in CF and non-CF bronchiectasis patients. Cross-sectional retrospective/prospective controlled study assessing CPET using cycle ergometer. Exercise parameters and computed tomography (CT) findings were compared. Results: Hundred two patients with bronchiectasis and 88 controls were evaluated; 49 CF (age 19.7 ± 9.7 y/o, FEV1%predicted 70.9 ± 20.5%) and 53 non-CF (18.6 ± 10.6 y/o, FEV1%predicted 68.7 ± 21.5%). Peak oxygen uptake (peak [Formula: see text]) was similar and relatively preserved in both groups (CF 1915.5±702.0; non-CF 1740±568; control 2111.0±748.3 mL/min). Breathing limitation was found in the two groups vs. control; low breathing reserve (49% in CF; 43% non-CF; 5% control) and increased [Formula: see text] (CF 31.4±4.1, non-CF 31.7±4.1 and control 27.2 ± 2.8). Oxygen pulse was lower in the non-CF; whereas a linear relationship between peak [Formula: see text] vs. FEV1 and vs. FVC was found only for CF. CT score correlated with [Formula: see text] and negatively correlated with [Formula: see text] and post exercise oxygen saturation (SpO2). CPET parameters may differ between CF and non-CF bronchiectasis. However, normal exercise capacity may be found unrelated to the etiology of the bronchiectasis. Anatomical changes in CT are associated with functional finding of increased [Formula: see text] and decreased SpO2. Larger longitudinal studies including cardiac assessment are needed to better study exercise capacity in different etiologies of non-CF bronchiectasis. ClinicalTrials.gov, registration number: NCT03147651.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0217491