Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?

Neuroendocrine neoplasms (NENs) can arise in most of the epithelial organs of the body and are not a rare condition in the gastrointestinal tract (GIT). The presence of NENs in GIT associated with other secondary primary malignancies (SPM) has been considered an exotic event. This study aims to desc...

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Bibliographic Details
Published in:PloS one 2019-05, Vol.14 (5), p.e0216647-e0216647
Main Authors: Parra-Medina, Rafael, Moreno-Lucero, Paula, Jimenez-Moreno, Julian, Parra-Morales, Alejandra María, Romero-Rojas, Alfredo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Autocrine signalling
Biology and Life Sciences
Cancer
Cancer metastasis
Cancer research
Carcinoma
Case reports
Esophagus
Gastric cancer
Gastrointestinal Neoplasms - etiology
Gastrointestinal system
Gastrointestinal tract
Gastrointestinal tumors
Gene expression
Humans
Large intestine
Ligands
Localization
Lung cancer
Lymphoma
Lymphomas
Medicine and Health Sciences
Metastases
Neoplasms
Neoplasms, Multiple Primary - etiology
Neuroendocrine tumors
Neuroendocrine Tumors - etiology
Organs
Paracrine signalling
Pathology
Small intestine
Squamous cell carcinoma
Stomach
Stomach cancer
Systematic review
Tumors
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Summary:Neuroendocrine neoplasms (NENs) can arise in most of the epithelial organs of the body and are not a rare condition in the gastrointestinal tract (GIT). The presence of NENs in GIT associated with other secondary primary malignancies (SPM) has been considered an exotic event. This study aims to describe the case reports of NENs accompanied by synchronous primary tumors. We performed a systematic literature search of the databases Scopus, PubMed, Scielo and LILACS to identify case reports that described the presence of NENs in GIT with SPM. 78 case reports were included. The mean of age of the cases was 60.2 years. 60% were male. 95.4% were NENs G1. 17 cases of NENs had metastasis. 80% of SPM were recognized in the GIT (36% in stomach, 27% in large intestine, 11.2% in small intestine, and 5.6% in esophagus). The most common type of SPM was adenocarcinoma (49.4%), followed by GIST (13.5%), other NENs in different GIT segment (7.9%), lymphoma (6.8%), and squamous cell carcinoma (4.5%). The most common tumor in GIT was adenocarcinoma (97.6%) and the presence of adenocarcinoma in the same segment of GIT was found in 68.4% of the cases. Association between adenocarcinomas and NENs in GIT (p:
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0216647