Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging

To evaluate the influence of an active inflammatory process in the liver on Gd-EOB-DTPA-enhanced MR imaging in patients with different degrees of fibrosis/cirrhosis. Overall, a number of 91 patients (61 men and 30 women; mean age 58 years) were included in this retrospective study. The inclusion cri...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-05, Vol.14 (5), p.e0215752-e0215752
Main Authors: Verloh, N, Probst, U, Utpatel, K, Zeman, F, Brennfleck, F, Werner, J M, Fellner, C, Stroszczynski, C, Evert, M, Wiggermann, P, Haimerl, M
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Biology and Life Sciences
Cirrhosis
Contrast Media
Correlation
Diagnosis
Diagnostic imaging
Female
Fibrosis
Gadolinium
Gadolinium DTPA
Gastroenterology
Hepatitis
Hepatology
Hospitals
Humans
Inflammation
Inflammation - diagnostic imaging
Inflammation - pathology
Influence
Liver
Liver - diagnostic imaging
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Magnetic Resonance Imaging
Male
Medical imaging
Medicine and Health Sciences
Middle Aged
Necrosis
NMR
Nuclear magnetic resonance
Pathological histology
Pathology
Patient compliance
Patients
Regression Analysis
Research and Analysis Methods
Retrospective Studies
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the influence of an active inflammatory process in the liver on Gd-EOB-DTPA-enhanced MR imaging in patients with different degrees of fibrosis/cirrhosis. Overall, a number of 91 patients (61 men and 30 women; mean age 58 years) were included in this retrospective study. The inclusion criteria for this study were Gd-EOB-DTPA-enhanced MRI of the liver and histopathological evaluation of fibrotic and inflammatory changes. T1-weighted VIBE sequences of the liver with fat suppression were evaluated to determine the relative signal change (RE) between native and hepatobiliary phase (20min). In simple and multiple linear regression analyses, the influence of liver fibrosis/cirrhosis (Ishak score) and the histopathological degree of hepatitis (Modified Hepatic Activity Index, mHAI) on RE were evaluated. RE decreased significantly with increasing liver fibrosis/cirrhosis (p < 0.001) and inflammation (mHAI, p = 0.004). In particular, a correlation between RE and periportal or periseptal boundary zone hepatitis (moth feeding necrosis, mHAI A, p = 0.001) and portal inflammation (mHAI D, p < 0.001) was observed. In multiple linear regression analysis, both the degree of inflammation and the degree of fibrosis were significant predictors for RE (p < 0.01). The results of this study suggest that the MR-based hepatic enhancement index RE is not only influenced by the degree of fibrosis, but also by the degree of inflammation.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0215752