Big data and analysis of risk factors for gallbladder disease in the young generation of Korea

Few studies have examined the risk factors for gallbladder (GB) disease in young adults. This study aimed to evaluate risk factors for GB disease in young adults based on big data in Korea. All participants underwent routine checkup at the Korea Medical Institute from June 2014 to May 2015. After ex...

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Bibliographic Details
Published in:PloS one 2019-02, Vol.14 (2), p.e0211480
Main Authors: Kim, Hyung Sun, Cho, Seong Kyung, Kim, Chang Soo, Park, Joon Seong
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Big Data
Biology and Life Sciences
Blood
Body mass
Body Mass Index
Body measurements
Body size
Cholesterol
Cholesterol - blood
Data management
Data processing
Demographic aspects
Density
Diet
Female
Gallbladder
Gallbladder diseases
Gallbladder Diseases - complications
Gallbladder Diseases - epidemiology
Gallstones
Gallstones - complications
Gallstones - epidemiology
Health risks
High density lipoprotein
Hospitals
Humans
Laboratories
Levels
Lipoproteins
Low density lipoprotein
Low density lipoproteins
Male
Medical research
Medical screening
Medicine and Health Sciences
Men
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Nutrition research
Obesity
Obesity - complications
Obesity - epidemiology
People and Places
Polyps
Prevalence
Preventive medicine
Republic of Korea - epidemiology
Risk analysis
Risk Factors
Sludge
Smoking
Statistical analysis
Studies
Thigh
Trends
Triglycerides - blood
Ultrasound
Ultrasound imaging
Waist Circumference
Weight control
Womens health
Young adults
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Summary:Few studies have examined the risk factors for gallbladder (GB) disease in young adults. This study aimed to evaluate risk factors for GB disease in young adults based on big data in Korea. All participants underwent routine checkup at the Korea Medical Institute from June 2014 to May 2015. After excluding 677 individuals with missing information in records, 724,114 individuals (435,635 men, 288,479 women) were finally included. The definition of abnormal GB finding included stones, sludge, polyps, and adenomyomatosis detected using ultrasonography. All statistical analyses were performed using SAS software version 9.2. Overall, 27,130 (17.5%) individuals were diagnosed as having abnormal GB finding in the young age group (N = 154,463, aged 20-39 years). In men, significant differences in low-density lipoprotein (LDL) and cholesterol levels were observed between the abnormal GB finding group and normal GB group (p < 0.05). In women, a significant difference in smoking history was noted between the abnormal GB finding group and normal GB group (p < 0.05). The prevalence rate of GB stones was 1.9% (27,979/154,463) in the young age group. High body mass index (BMI), large thigh circumference, and low high-density lipoprotein (HDL) level in women and low HDL level in men were independent risk factors for the presence of GB stones (p < 0.05). In this study, obesity-related factors (BMI, waist size, thigh circumference, and cholesterol, LDL, and HDL levels) correlated with GB disease in the young generation of Korea.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0211480