The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome

Spot 14 (S14) protein is primarily expressed in adipogenic tissues. Compared to wild type, S14 knockout mice had better resistance to diet-induced obesity and glucose tolerance. However, the association between serum S14 level and metabolic variables in humans has never been investigated. The object...

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Bibliographic Details
Published in:PloS one 2019-02, Vol.14 (2), p.e0212341-e0212341
Main Authors: Chen, Yen-Ting, Tseng, Ping-Huei, Tseng, Fen-Yu, Chi, Yu-Chiao, Han, Der-Sheng, Yang, Wei-Shiung
Format: Article
Language:English
Subjects:
Adult
Aged
Biology and Life Sciences
Blood pressure
Body fat
Breast cancer
Care and treatment
Cholesterol
Cholesterol, LDL - blood
Clinical medicine
Cross-Sectional Studies
Development and progression
Diabetes
Endocrinology
Enzymes
Fasting
Fatty acids
Female
Gene expression
Genetic aspects
Genetic transformation
Genotypes
Glucose
Glucose tolerance
Health aspects
Hemoglobin
Hepatitis
High density lipoprotein
Hospitals
Human subjects
Humans
Hyperlipidemia
Hypertriglyceridemia
Insulin
Internal medicine
Linear Models
Logistic Models
Male
Medicine
Medicine and Health Sciences
Metabolic diseases
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - pathology
Middle Aged
Nuclear Proteins - blood
Nutrition research
Obesity
Obesity, Abdominal - complications
Odds Ratio
Proteins
Risk Factors
Serum levels
Thyroid gland
Transcription Factors - blood
Transformation
Triglycerides
Triglycerides - blood
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Summary:Spot 14 (S14) protein is primarily expressed in adipogenic tissues. Compared to wild type, S14 knockout mice had better resistance to diet-induced obesity and glucose tolerance. However, the association between serum S14 level and metabolic variables in humans has never been investigated. The objectives of this study were to evaluate the associations between serum S14 concentrations with components of metabolic syndrome (MetS). A total of 327 subjects were recruited in this cross-sectional study and categorized by presence of MetS. The mean serum levels of S14 were significantly lower in subjects with MetS than those without (87.1±26.3 μg/L vs. 107.3±40.2 μg/L, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0212341