Epidemiological profile of dengue in Zhejiang Province, southeast China

Dengue is one of the most important vector-bore infectious diseases in China because of its drastic increase in incidence, geographic extension and profound influence on China's economy. This study aims to retrospectively uncover the epidemiological profile of dengue in Zhejiang, one of the mos...

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Bibliographic Details
Published in:PloS one 2018-12, Vol.13 (12), p.e0208810-e0208810
Main Authors: Ren, Jiangping, Ling, Feng, Sun, Jimin, Gong, Zhenyu, Liu, Ying, Shi, Xuguang, Zhang, Rong, Zhai, Yujia, Chen, Enfu, Chen, Zhiping
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis
Biology and life sciences
China
Cities and towns
Communicable diseases
Control
Dengue
Dengue - epidemiology
Dengue fever
Disease control
Disease Outbreaks
Disease prevention
Disease transmission
Distribution
Earth Sciences
Epidemics
Epidemiology
Fatigue
Fatigue tests
Female
Fever
Headache
Humans
Incidence
Infections
Infectious diseases
Intervals
Laboratories
Male
Medicine and Health Sciences
Middle Aged
Mortality
Myalgia
Outbreaks
People and Places
Prevention
Provinces
Public health
Rash
Sex ratio
Systematic review
Tidal bores
Vaccines
Vector-borne diseases
Viral diseases
Young Adult
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Summary:Dengue is one of the most important vector-bore infectious diseases in China because of its drastic increase in incidence, geographic extension and profound influence on China's economy. This study aims to retrospectively uncover the epidemiological profile of dengue in Zhejiang, one of the most developed provinces in China, and to find the problem existing in dengue control and prevention. Descriptive analyses on the dengue incidence and associated factors were performed. We also identified potential space-time cluster and generated the risk map of dengue. A total of 529 cases were reported in Zhejiang Province from 2005 to 2016, and 44.4% were imported. 67.7% of cases were 25~60 years old and the overall male-to-female sex ratio was 1.09:1. Dengue was reported all year round and 70.7% of cases occurred between August and October. Indigenous cases were only reported in the period between July to November and more than half occurred in September. Geographically, dengue was most distributed in Jinghua (3.62 per million), Shaoxing (1.00 per million) and Taizhou (0.81 per million) prefecture level cities. Outbreaks were confirmed in Yiwu, Keqiao and Huangyan counties in 2009, 2015, and 2016, respectively. 73.9% cases would seek medical advice within two days after onset and be confirmed within 9 days after onset. 75.6% would be recognized as dengue within 8 days after their first visit. The time intervals between onset and confirmation (median 7 vs 6 days; Wilcoxon rank sum test Z = -2.40, P = 0.016), first visit and confirmation (median 7 vs 6 days; Wilcoxon rank sum test Z = -2.59, P = 0.009) of indigenous cases were significantly longer than those of imported ones. However, the time intervals between onset and first visit for indigenous cases was shorter (median 0 vs 1 days; Wilcoxon rank sum test Z = -2.10, P = 0.036). Fever (99.1%), fatigue (81.9), rash (63.7%), headache (67.2%) and myalgia (52.60%) were the most frequently mentioned symptoms. Zhejiang has recently witnessed an increase in incidence and geographic extension of dengue. Timely diagnosis is important to stop local transmission and outbreak.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0208810