Emerging Shiga-toxin-producing Escherichia coli serogroup O80 associated hemolytic and uremic syndrome in France, 2013-2016: Differences with other serogroups

To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013...

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Bibliographic Details
Published in:PloS one 2018, Vol.13 (11), p.e0207492-e0207492
Main Authors: Ingelbeen, Brecht, Bruyand, Mathias, Mariani-Kurkjian, Patricia, Le Hello, Simon, Danis, Kostas, Sommen, Cécile, Bonacorsi, Stéphane, de Valk, Henriette
Format: Article
Language:English
Subjects:
Age
Animals
Bacteria
Bacteriology
Biology and Life Sciences
Child, Preschool
Children
Confidence intervals
Diarrhea
Diarrhea - epidemiology
Diarrhea - microbiology
Disease prevention
E coli
Epidemiology
Escherichia coli
Female
Food
France - epidemiology
Health risks
Health surveillance
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - microbiology
Human health and pathology
Humans
Infant
Infections
Infectious diseases
Life Sciences
Male
Medicine and Health Sciences
Microbiology and Parasitology
Patients
Pediatrics
People and places
Public health
Questionnaires
Red Meat - microbiology
Research and Analysis Methods
Retrospective Studies
Risk analysis
Risk factors
Santé publique et épidémiologie
Serogroup
Shiga toxin
Shiga-Toxigenic Escherichia coli
Zoonoses
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Summary:To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013-16. STEC was isolated from 153/521 (30%) reported HUS cases: 45 serogroup O80, 46 O157 and 62 other serogroups. Median ages were 1.1 years, 4.0 years and 1.8 years, respectively. O80 infected patients were less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0.14 95% CI [Confidence Interval] 0.02-0.80) or previous contact with a person with diarrhea or HUS (aOR 0.13 95%CI 0.02-0.78) than patients infected with STEC O157. They were also less likely to report previous contact with a person presenting with diarrhea/HUS than patients infected with other serogroups (aOR 0.13 95%CI 0.02-0.78). STEC O80 spread all over France among young children less exposed to known risk factors of O157 or other STEC infections, suggesting the existence of different reservoirs and transmission patterns.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0207492