Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance

Hydrocephalus is a debilitating disorder, affecting all age groups. Evaluation of its global epidemiology is required for healthcare planning and resource allocation. To define age-specific global prevalence and incidence of hydrocephalus. Population-based studies reporting prevalence of hydrocephal...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0204926-e0204926
Main Authors: Isaacs, Albert M, Riva-Cambrin, Jay, Yavin, Daniel, Hockley, Aaron, Pringsheim, Tamara M, Jette, Nathalie, Lethebe, Brendan Cord, Lowerison, Mark, Dronyk, Jarred, Hamilton, Mark G
Format: Article
Language:English
Subjects:
Adults
Age
Aging (Biology)
Biology and Life Sciences
Birth
Birth defects
Bone surgery
Brain cancer
Computer and Information Sciences
Congenital defects
Data collection
Demographic aspects
Epidemiology
Folic acid
Geriatrics
Health care
Heterogeneity
Hydrocephalus
Identification methods
Incidence
Income
Literature reviews
Medical prognosis
Medicine and Health Sciences
Meningitis
Meta-analysis
Neurology
Neurosciences
Neurosurgery
Older people
Pediatrics
People and Places
Physiological aspects
Population studies
Prevalence studies (Epidemiology)
Regression analysis
Research and Analysis Methods
Resource allocation
Risk factors
Scientific papers
Studies
Surveillance
Systematic review
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Summary:Hydrocephalus is a debilitating disorder, affecting all age groups. Evaluation of its global epidemiology is required for healthcare planning and resource allocation. To define age-specific global prevalence and incidence of hydrocephalus. Population-based studies reporting prevalence of hydrocephalus were identified (MEDLINE, EMBASE, Cochrane, and Google Scholar (1985-2017)). Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Two authors reviewed abstracts, full text articles and abstracted data. Metanalysis and meta-regressions were used to assess associations between key variables. Heterogeneity and publication bias were assessed. Main outcome of interest was hydrocephalus prevalence among pediatric (≤ 18 years), adults (19-64 years), and elderly (≥ 65) patients. Annual hydrocephalus incidence stratified by country income level and folate fortification requirements were obtained (2003-2014) from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). Of 2,460 abstracts, 52 met review eligibility criteria (aggregate population 171,558,651). Mean hydrocephalus prevalence was 85/100,000 [95% CI 62, 116]. The prevalence was 88/100,000 [95% CI 72, 107] in pediatrics; 11/100,000 [95% CI 5, 25] in adults; and 175/100,000 [95% CI 67, 458] in the elderly. The ICBDSR-based incidence of hydrocephalus diagnosed at birth remained stable over 11 years: 81/100,000 [95% CI 69, 96]. A significantly lower incidence was identified in high-income countries. This systematic review established age-specific global hydrocephalus prevalence. While high-income countries had a lower hydrocephalus incidence according to the ICBDSR registry, folate fortification status was not associated with incidence. Our findings may inform future healthcare resource allocation and study.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0204926