The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis

This study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language...

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Bibliographic Details
Published in:PloS one 2018-09, Vol.13 (9), p.e0202620-e0202620
Main Authors: Wang, Guobin, Niu, Jianhua, Li, Zhitao, Lv, Haifeng, Cai, Hongliu
Format: Article
Language:English
Subjects:
Analgesics, Non-Narcotic - adverse effects
Analgesics, Non-Narcotic - therapeutic use
Anesthesia
Blood pressure
Bradycardia
Cardiac patients
Cardiac Surgical Procedures - methods
Clinical trials
Confidence intervals
Congenital diseases
Data processing
Dexmedetomidine
Dexmedetomidine - adverse effects
Dexmedetomidine - therapeutic use
Dosage and administration
Effectiveness
Fibrillation
Health aspects
Heart rate
Heart surgery
Hemodynamics
Hospitals
Humans
Hypotension
Intensive Care Units
Medical research
Medicine and Health Sciences
Mental disorders
Meta-analysis
Operative Time
Patients
Physical Sciences
Postoperative Complications - epidemiology
Randomized Controlled Trials as Topic
Research and Analysis Methods
Safety
Safety and security measures
Studies
Surgery
Systematic review
Tachycardia
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Summary:This study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language and publication time. Randomized controlled trials (RCTs) aiming to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients that have undergone cardiac surgery were selected. Endpoints such as hemodynamic indexes and adverse events in eligible studies were extracted by two researchers, independently. The data was analyzed using RevMan 5.3 and Stata 11.0 software. A total of 18 RCTs met the inclusion criteria, involving 1730 patients. Compared to control (any treatment without dexmedetomidine), dexmedetomidine showed a pooled mean difference (MD) of -14.46 [95% confidence interval(CI): -24.69, -4.23; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0202620