Drug susceptibility testing of slowly growing non-tuberculous mycobacteria using slomyco test-system

The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system. We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. intracellulare), 112 M. kansasii...

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Bibliographic Details
Published in:PloS one 2018-09, Vol.13 (9), p.e0203108-e0203108
Main Authors: Litvinov, Vitalii, Makarova, Marina, Galkina, Ksenia, Khachaturiants, Elena, Krasnova, Maria, Guntupova, Lidia, Safonova, Svetlana
Format: Article
Language:English
Subjects:
Amikacin
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biology and Life Sciences
Chemotherapy
Ciprofloxacin
Clarithromycin
Confidence intervals
Diagnostic systems
Dose-Response Relationship, Drug
Doxycycline
Drug Resistance, Bacterial
Drugs
Ethambutol
Ethionamide
Humans
Inhibition
Isoniazid
Laboratories
Linezolid
Medical screening
Medicine and Health Sciences
Methods
Microbial Sensitivity Tests - instrumentation
Microbial Sensitivity Tests - methods
Moxifloxacin
Mycobacterium Infections, Nontuberculous - drug therapy
Nontuberculous Mycobacteria - drug effects
Nontuberculous Mycobacteria - isolation & purification
Polystyrene
Polystyrene resins
Rank tests
Rifabutin
Rifampin
Significance
Species Specificity
Statistical analysis
Statistical significance
Streptomycin
Sulfamethoxazole
Trimethoprim
Tuberculosis
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Summary:The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system. We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. intracellulare), 112 M. kansasii and 74 M. xenopi collected from the respiratory material of the patients were under the treatment or under diagnostic procedures at our Center, affiliates and the diagnostic department in 2010-2016. Drug sucseptibility for NTM was tested using the Sensititre SLOWMYCO system (TREK DIAGNOSTIC Systems Ltd., UK). MICs were established by microdilutions in Mueller-Hinton broth on polystyrene 96-well plates. The statistical analysis was done using the StatGraphics Plus 5.0 software. The data were compared pairwise using Pearson χ2 test with Yates correction. 95% confidence interval (CI) were calculated. Statistically significant differences were considered for p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203108