Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects on several gastrointestinal disorders. The objectives of thi...

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Bibliographic Details
Published in:PloS one 2018-08, Vol.13 (8), p.e0202929
Main Authors: Filipescu, Iulia Elena, Leonardi, Leonardo, Menchetti, Laura, Guelfi, Gabriella, Traina, Giovanna, Casagrande-Proietti, Patrizia, Piro, Federica, Quattrone, Alda, Barbato, Olimpia, Brecchia, Gabriele
Format: Article
Language:English
Subjects:
Anaerobes
Animals
Antigens
Bacteria
Bacterial Load
Binding sites
Biology and Life Sciences
Body weight
Care and treatment
Cattle
Colitis
Colitis - chemically induced
Colitis - prevention & control
Colostrum
Cytokines
Cytokines - metabolism
Damage tolerance
Disease
E coli
Gastrointestinal diseases
Gastrointestinal Microbiome
Gene expression
Genetic aspects
Health aspects
Homeostasis
Immune system
Immunology
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Inoculation
Interleukin 10
Interleukin 8
Intestinal microflora
Intestine
Lactobacilli
Lymphocytes
Male
Medicine and Health Sciences
Mice
Microbiota
Molecular modelling
Pathogenesis
Permeability
Properties
Protective Agents - therapeutic use
Proteins
Research and Analysis Methods
Rodents
Saline solutions
Sulfonic acid
Sulfonic acids
Supplements
TLR4 protein
Toll-Like Receptor 4 - metabolism
Toll-like receptors
Trinitrobenzenesulfonic Acid
Tumor necrosis factor-α
Veterinary medicine
Weight reduction
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Summary:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects on several gastrointestinal disorders. The objectives of this study were to assess the preventive effects of BC supplementation in a mouse model of 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis using a multidisciplinary approach. Specifically, the following parameters were evaluated: (i) disease activity index (DAI), (ii) histological score, (iii) expression levels of TLR4, anti- and pro-inflammatory cytokines, and (iv) count of some bacterial species of the intestinal microbiota. Mice received a daily suspension of BC (BC group, n = 12) or saline solution (control, CN group, n = 12) for 21 days before the intrarectal inoculation with 1% of TNBS solution. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, BC group showed a reduction of body weight (BW) loss (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0202929