Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study

Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. We examined the association between the phototype and breast and prostate...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-08, Vol.13 (8), p.e0201750-e0201750
Main Authors: Gómez-Acebo, Inés, Dierssen-Sotos, Trinidad, Palazuelos, Camilo, Fernández-Navarro, Pablo, Castaño-Vinyals, Gemma, Alonso-Molero, Jéssica, Urtiaga, Carmen, Fernández-Villa, Tania, Ardanaz, Eva, Rivas-Del-Fresno, Manuel, Molina-Barceló, Ana, Jiménez-Moleón, José-Juan, García-Martinez, Lidia, Amiano, Pilar, Rodriguez-Cundin, Paz, Moreno, Víctor, Pérez-Gómez, Beatriz, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, Llorca, Javier
Format: Article
Language:English
Subjects:
Age
Analysis
Biology and Life Sciences
Breast cancer
Cancer
Cancer research
Càncer de mama
Càncer de pròstata
Diagnosis
Epidemiology
Espanya
Estrogens
Fenotip
Health aspects
Health risk assessment
Health risks
Hematology
Hospitals
Medical research
Medicine and Health Sciences
Oncology
Patient outcomes
Phenotype
Physical sciences
Pigmentation
Population
Prostate cancer
Public health
Randomization
Risk factors
Skin
Skin cancer
Smoking
Spain
Studies
Vitamin D
Vitamin deficiency
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. Phototype is not associated with breast or prostate cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0201750