Phylogenetic analysis of canine distemper virus in South African wildlife

Canine distemper virus (CDV) causes a severe contagious disease in a broad range of hosts. This is the first study to genetically characterise CDV strains from four different wildlife species in South Africa. The phylogenetic diversity of CDV is examined, using the haemagglutinin gene. The South Afr...

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Bibliographic Details
Published in:PloS one 2018-07, Vol.13 (7), p.e0199993-e0199993
Main Authors: Loots, Angelika K, Mokgokong, Prudent S, Mitchell, Emily, Venter, Estelle H, Kotze, Antoinette, Dalton, Desiré Lee
Format: Article
Language:English
Subjects:
Amino acids
Biodiversity
Biology and Life Sciences
Canidae
Canine distemper
Canis lupus dingo
Carnivores
Computer and Information Sciences
Disease
Dogs
Epidemics
Gene expression
Genetic aspects
Genotypes
Hemagglutinins
Infections
Lycaon pictus
Medicine and Health Sciences
Mortality
Nectin
Pathogenesis
People and places
Phylogenetics
Phylogeny
Proteins
Research and Analysis Methods
Species diversity
Strains (organisms)
Tropical diseases
Viruses
Wildlife
Zoology
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Summary:Canine distemper virus (CDV) causes a severe contagious disease in a broad range of hosts. This is the first study to genetically characterise CDV strains from four different wildlife species in South Africa. The phylogenetic diversity of CDV is examined, using the haemagglutinin gene. The South African wildlife CDV isolates showed a high degree of similarity to CDV in South African domestic dogs. Phylogenetic analyses confirmed the presence of 12 geographical lineages with CDV strains from South African wildlife falling within the Southern African lineage. The study reveals two possible co-circulating sub-genotypes corresponding to the northern and southern regions of South Africa respectively. CDV strains from the non-canid species were distinct, but similar to CDV isolates from domestic dog and wild canids. Residues at amino acid sites of the SLAM binding region support the notion that CDV strains encoding 519I / 549H are better adapted to non-canid species than canid species. The amino acids present at site 530 are conserved regardless of host species. Strains from South African wild carnivores showed no difference between host species with all strains presenting 530N. All non-canid strains in this study presented the combination 519I/549H. No evidence of host adaptation or lineage grouping was observed for the Nectin-4 binding region. Further studies should include CDV strains isolated from various hosts from a wider geographical range in South Africa.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0199993