Circulating levels of sclerostin are associated with cardiovascular mortality

Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently...

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Published in:PloS one 2018-06, Vol.13 (6), p.e0199504-e0199504
Main Authors: Novo-Rodríguez, Cristina, García-Fontana, Beatriz, Luna-Del Castillo, Juan De Dios, Andújar-Vera, Francisco, Ávila-Rubio, Verónica, García-Fontana, Cristina, Morales-Santana, Sonia, Rozas-Moreno, Pedro, Muñoz-Torres, Manuel
Format: Article
Language:English
Subjects:
Atherosclerosis
Biology and Life Sciences
Biomarkers
Bone Morphogenetic Proteins - blood
Calcification
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
Cohort Studies
Complications and side effects
Development and progression
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - mortality
Diagnosis
Endocrinology
Female
Females
Gene expression
Genetic Markers
Glucose
Health risks
Hemoglobin
Hospitals
Humans
Incidence
Kaplan-Meier Estimate
Logistic Models
Male
Medicine and Health Sciences
Metabolism
Middle Aged
Mortality
Normal distribution
Nutrition
Patient outcomes
Physical Sciences
Proportional Hazards Models
Risk analysis
Risk Factors
ROC Curve
Signal transduction
SOST protein
Type 2 diabetes
Wnt protein
Womens health
β-Catenin
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Summary:Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% females; 75 with type 2 diabetes; 46 with prevalent cardiovascular disease) in which serum sclerostin levels were measured at the baseline. Time to death (both of cardiovascular and non-cardiovascular causes) was assessed to establish the relationship between sclerostin and mortality. We found that serum sclerostin concentrations were significantly higher in patients with prevalent cardiovascular disease (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0199504