Macular choroidal thickness and peripapillary retinal nerve fiber layer thickness in normal adults and patients with optic atrophy due to acute idiopathic demyelinating optic neuritis

To evaluate the association between macular choroidal thickness and peripapillary RNFL thickness in patients with optic atrophy due to acute idiopathic demyelinating optic neuritis and in normal controls using spectral domain optical coherence tomography (SD-OCT). We performed SD-OCT peripapillary R...

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Bibliographic Details
Published in:PloS one 2018-06, Vol.13 (6), p.e0198340-e0198340
Main Authors: Park, Kyung-Ah, Choi, Daye Diana, Oh, Sei Yeul
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Adults
Atrophy
Biology and Life Sciences
Care and treatment
Case-Control Studies
Choroid - anatomy & histology
Choroid - pathology
Complications and side effects
Demyelinating Diseases - complications
Demyelinating Diseases - pathology
Demyelination
Development and progression
Eye
Eye (anatomy)
Female
Fovea
Glaucoma
Horizontal cells
Humans
Male
Medical examination
Medical imaging
Medicine and Health Sciences
Middle Aged
Multiple sclerosis
Multivariate analysis
Neuritis
Optic atrophy
Optic Atrophy - etiology
Optic Atrophy - pathology
Optic Disk - anatomy & histology
Optic Disk - pathology
Optic nerve
Optic neuritis
Optic Neuritis - complications
Optic Neuritis - pathology
Optical Coherence Tomography
Optical tomography
Optics
Organ Size
Patients
Physical Sciences
Research and Analysis Methods
Retina
Retinal Ganglion Cells - pathology
Social Sciences
Thickness measurement
Tomography, Optical Coherence
Visual Fields
Young Adult
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Summary:To evaluate the association between macular choroidal thickness and peripapillary RNFL thickness in patients with optic atrophy due to acute idiopathic demyelinating optic neuritis and in normal controls using spectral domain optical coherence tomography (SD-OCT). We performed SD-OCT peripapillary RNFL circular scan centered on the optic disc with horizontal and vertical crosshair scans through the fovea using the enhanced depth technique in 62 eyes with optic atrophy due to acute idiopathic demyelinating optic neuritis and 86 eyes of normal controls. The association between RNFL thickness and macular choroidal thickness measurements was assessed. The mean age was 43 ± 14 years (mean ± SD) in patients with optic atrophy and 45 ± 16 years in healthy controls (p = 0.791). There was a significant association between nasal peripapillary RNFL thickness and choroidal thickness at 3.0 mm nasal to the foveal center in patients with optic atrophy in multivariate analysis (estimate = 1.398, p = 0.011). In controls, there were significant associations between global average, superior, and inferior peripapillary RNFL thickness and choroidal thickness at 3.0 mm superior to the foveal center (estimate = -60.112, p = 0.044, estimate = 15.821, p = 7.312, and estimate = 15.203, p = 7.222, respectively). Our SD-OCT data revealed that there was a significant association between peripapillary RNFL thickness and macular choroidal thickness in patients with optic atrophy due to acute idiopathic demyelinating optic neuritis and in controls, although the mechanism remained unclear. The difference in the pattern of association between patients with optic atrophy and controls suggests that optic atrophy caused by acute idiopathic demyelinating optic neuritis could affect the pattern of association between peripapillary RNFL thickness and macular choroidal thickness.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0198340