Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas

Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly und...

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Bibliographic Details
Published in:PloS one 2018-05, Vol.13 (5), p.e0196235-e0196235
Main Authors: Stretch, Cynthia, Aubin, Jean-Michel, Mickiewicz, Beata, Leugner, Derek, Al-Manasra, Tariq, Tobola, Elizabeth, Salazar, Santiago, Sutherland, Francis R, Ball, Chad G, Dixon, Elijah, Vogel, Hans J, Damaraju, Sambasivario, Baracos, Vickie E, Bathe, Oliver F
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adipose tissue
Bioinformatics
Biological markers
Biology and Life Sciences
Body composition
Cancer therapies
Carbohydrate metabolism
Carbohydrates
Care and treatment
Catabolism
Computed tomography
Diabetes
Diagnosis
DNA microarrays
Funding
Gas chromatography
Gene expression
Hepatitis
Identification and classification
Infiltration
Insulin resistance
Laboratories
Liver cancer
Magnetic resonance spectroscopy
Mass spectrometry
Mass spectroscopy
Medical imaging
Medical prognosis
Medicine and Health Sciences
Metabolism
Metabolites
Metastases
Muscles
Musculoskeletal system
NMR spectroscopy
Obesity
Oncology
Oxidative phosphorylation
Pancreatic cancer
Pancreaticoduodenectomy
Patients
Phenotypes
Phosphorylation
Physical Sciences
Physiological aspects
Research and Analysis Methods
Sarcopenia
Spectroscopy
Subgroups
Surgery
Survival
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Summary:Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly understood. Clinical characteristics and outcomes were studied in 123 patients who underwent pancreaticoduodenectomy for pancreatic or non-pancreatic periampullary adenocarcinoma and who had available preoperative CT scans. In a subgroup of patients with pancreatic cancer (n = 29), rectus abdominus muscle mRNA expression was determined by cDNA microarray and in another subgroup (n = 29) 1H-NMR spectroscopy and gas chromatography-mass spectrometry were used to characterize the serum metabolome. Muscle mass and radiodensity were not significantly correlated. Distinct groups were identified: sarcopenia (40.7%), myosteatosis (25.2%), both (11.4%). Fat distribution differed in these groups; sarcopenia associated with lower subcutaneous adipose tissue (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0196235