An atlas of Wnt activity during embryogenesis in Xenopus tropicalis

Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and det...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0193606-e0193606
Main Authors: Borday, Caroline, Parain, Karine, Thi Tran, Hong, Vleminckx, Kris, Perron, Muriel, Monsoro-Burq, Anne H
Format: Article
Language:English
Subjects:
Biological research
Biology and Life Sciences
Cognitive Sciences
Embryogenesis
Embryonic development
Embryonic growth stage
Embryos
Gene expression
Heparan sulfate
Life Sciences
Ligands
Molecular biology
Neural crest
Neural tube
Neurobiology
Neurons and Cognition
Neurosciences
Physiological aspects
Proteins
Psychology and behavior
Research and Analysis Methods
Retina
Signaling
Wnt protein
Wnt proteins
Xenopus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0193606