Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices

We aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and 660 controls from 2008-2011 in Melbourne, Australi...

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Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0193992-e0193992
Main Authors: Ponsonby, Anne-Louise, Pezic, Angela, Cameron, Fergus J, Rodda, Christine, Kemp, Andrew S, Carlin, John B, Hyoty, Heikki, Sioofy-Khojine, Amirbabak, Dwyer, Terence, Ellis, Justine A, Craig, Maria E
Format: Article
Language:English
Subjects:
Adults
Age
Biology and Life Sciences
Chicken pox
Children
Children & youth
Confidence intervals
Cytomegalovirus
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Epidemiology
Families & family life
Genomes
Health risks
Hospitals
Hygiene
Infections
Mediation
Medicine and Health Sciences
Microbiomes
Occupational health
Pediatrics
People and Places
Peripheral blood
Personal hygiene
Plasma
Polymerase chain reaction
Reverse transcription
Risk
Risk reduction
Virology
Viruses
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Summary:We aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and 660 controls from 2008-2011 in Melbourne, Australia. Enteroviral indices (ribonucleic acid by reverse transcription polymerase chain reaction and Coxsackie B virus antibody levels) in peripheral blood were measured in nested case control samples. Parent occupational social contact was assessed by the number of well or sick children, adults or animals contacted daily through work. Higher parental occupational social contact was strongly associated with reduced T1D risk with evidence of dose response (contact with the well or sick score, Adjusted odds ratio (AOR) per category: 0.73 (95% Confidence Interval (CI): 0.66, 0.81); P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0193992