Viral manipulation of STAT3: Evade, exploit, and injure

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or em...

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Bibliographic Details
Published in:PLoS pathogens 2018-03, Vol.14 (3), p.e1006839-e1006839
Main Authors: Roca Suarez, Armando Andres, Van Renne, Nicolaas, Baumert, Thomas F, Lupberger, Joachim
Format: Article
Language:English
Subjects:
Antiviral agents
Biochemistry, Molecular Biology
Biology and Life Sciences
Cancer
Cancer therapies
Cell adhesion & migration
Cytokines
Granulocytes
Growth factors
Hepatitis
Human health and pathology
Immune response
Immune system
Infectious diseases
Inflammation
Kinases
Life Sciences
Ligands
Medicine and health sciences
Phosphatase
Phosphorylation
Proteins
Psychological aspects
Review
Signal transduction
STAT3
Stat3 protein
Transcription
Transcription factors
Viruses
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Summary:Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006839