Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry

Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF and their association with patients' quality of life (QoL) and health outcomes. We used data on 6,480 patients with chronic HF (...

Full description

Saved in:

Bibliographic Details
Published in:	PLoS medicine 2018-03, Vol.15 (3), p.e1002541-e1002541
Main Authors:	Tromp, Jasper, Tay, Wan Ting, Ouwerkerk, Wouter, Teng, Tiew-Hwa Katherine, Yap, Jonathan, MacDonald, Michael R, Leineweber, Kirsten, McMurray, John J V, Zile, Michael R, Anand, Inder S, Richards, A Mark, Lam, Carolyn S P
Format:	Article
Language:	eng
Subjects:	Aged Aged, 80 and over Analysis Asia - epidemiology Asian Continental Ancestry Group Asians Atrial Fibrillation - complications Beta blockers Biology and Life Sciences Cardiomyopathy Care and treatment Comorbidity Demographics Demography Diabetes Complications - epidemiology Diabetes mellitus Etiology Female Fibrillation Geography Geriatrics Health aspects Health risk assessment Heart diseases Heart failure Heart Failure - complications Heart Failure - epidemiology Humans Hypertension Hypertension - complications Hypertension - epidemiology Ischemia Kaplan-Meier Estimate Latent Class Analysis Male Medicine and Health Sciences Middle Aged Mortality Multimorbidity Obesity Obesity - complications Obesity - epidemiology Older people Patient outcomes Patients People and Places Phenotype Phenotyping Prospective Studies Quality of Life Registries Severity of Illness Index Site selection Surveys and Questionnaires
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF and their association with patients' quality of life (QoL) and health outcomes. We used data on 6,480 patients with chronic HF (1,204 with preserved ejection fraction) enrolled between 1 October 2012 and 6 October 2016 in the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. The ASIAN-HF registry is a prospective cohort study, with patients prospectively enrolled from in- and outpatient clinics from 11 Asian regions (Hong Kong, Taiwan, China, Japan, Korea, India, Malaysia, Thailand, Singapore, Indonesia, and Philippines). Latent class analysis was used to identify patterns of multimorbidity. The primary outcome was defined as a composite of all-cause mortality or HF hospitalization within 1 year. To assess differences in QoL, we used the Kansas City Cardiomyopathy Questionnaire. We identified 5 distinct multimorbidity groups: elderly/atrial fibrillation (AF) (N = 1,048; oldest, more AF), metabolic (N = 1,129; obesity, diabetes, hypertension), young (N = 1,759; youngest, low comorbidity rates, non-ischemic etiology), ischemic (N = 1,261; ischemic etiology), and lean diabetic (N = 1,283; diabetic, hypertensive, low prevalence of obesity, high prevalence of chronic kidney disease). Patients in the lean diabetic group had the worst QoL, more severe signs and symptoms of HF, and the highest rate of the primary combined outcome within 1 year (29% versus 11% in the young group) (p for all
ISSN:	1549-1676 1549-1277 1549-1676