Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model - A preliminary study

Cancer affects 39.6% of Americans at some point during their lifetime. Solid tumor microenvironments are characterized by a disorganized, leaky vasculature that promotes regions of low oxygenation (hypoxia). Tumor hypoxia is a key predictor of poor treatment outcome for all radiotherapy (RT), chemot...

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Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0195667-e0195667
Main Authors: Fix, Samantha M, Papadopoulou, Virginie, Velds, Hunter, Kasoji, Sandeep K, Rivera, Judith N, Borden, Mark A, Chang, Sha, Dayton, Paul A
Format: Article
Language:English
Subjects:
Anemia
Animals
Bio-oxidative therapy
Biology and Life Sciences
Biomedical engineering
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Dissolved oxygen
Engineering
Female
Fibrosarcoma
Fibrosarcoma - metabolism
Fibrosarcoma - radiotherapy
Health aspects
Humans
Hypoxia
Medical prognosis
Medicine and Health Sciences
Metastases
Methods
Microbubbles
Microbubbles - therapeutic use
Microenvironments
Oncology
Oxygen
Oxygen - administration & dosage
Oxygen - metabolism
Oxygen - therapeutic use
Oxygen content
Oxygenation
Pharmacy
Physical Sciences
Radiation
Radiation dosage
Radiation therapy
Radiotherapy
Rats
Rats, Inbred F344
Research and Analysis Methods
Sarcoma, Experimental - metabolism
Sarcoma, Experimental - radiotherapy
Solid tumors
Surgery
Translational Research, Biomedical
Tumor Hypoxia - drug effects
Tumors
Ultrasonic imaging
Variation
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Summary:Cancer affects 39.6% of Americans at some point during their lifetime. Solid tumor microenvironments are characterized by a disorganized, leaky vasculature that promotes regions of low oxygenation (hypoxia). Tumor hypoxia is a key predictor of poor treatment outcome for all radiotherapy (RT), chemotherapy and surgery procedures, and is a hallmark of metastatic potential. In particular, the radiation therapy dose needed to achieve the same tumor control probability in hypoxic tissue as in normoxic tissue can be up to 3 times higher. Even very small tumors (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0195667