Does radiation therapy increase gadolinium accumulation in the brain?: Quantitative analysis of T1 shortening using R1 relaxometry in glioblastoma multiforme patients

This study evaluated the possibility of accelerated gadolinium accumulation in irradiated brain parenchyma where the blood-brain barrier was weakened. From January 2010 to June 2015, 44 patients with supratentorial glioblastoma were retrospectively identified who underwent pre- and post-radiation br...

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Bibliographic Details
Published in:PloS one 2018-02, Vol.13 (2), p.e0192838-e0192838
Main Authors: Lim, Woo Hyeon, Choi, Seung Hong, Yoo, Roh-Eul, Kang, Koung Mi, Yun, Tae Jin, Kim, Ji-Hoon, Sohn, Chul-Ho
Format: Article
Language:English
Subjects:
Accumulation
Biology and Life Sciences
Blood-brain barrier
Brain cancer
Brain damage
Brain injury
Brain mapping
Care and treatment
Damage accumulation
Development and progression
Gadolinium
Glioblastoma
Glioblastoma multiforme
Glioblastomas
Globus pallidus
Irradiated
Magnetic resonance imaging
Medicine
Medicine and Health Sciences
Multiple sclerosis
Neuroimaging
NMR
Nuclear magnetic resonance
Parenchyma
Patient outcomes
Patients
Physical Sciences
Physiological aspects
Post-radiation
Properties
Quantitative analysis
Radiation
Radiation dosage
Radiation therapy
Radiotherapy
Regression analysis
Research and Analysis Methods
Studies
Substantia alba
Thalamus
Tumors
Vials
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Summary:This study evaluated the possibility of accelerated gadolinium accumulation in irradiated brain parenchyma where the blood-brain barrier was weakened. From January 2010 to June 2015, 44 patients with supratentorial glioblastoma were retrospectively identified who underwent pre- and post-radiation brain MR imaging, including R1 mapping. The mean dose of administered gadobutrol (Gadovist, Bayer, Germany) was 5.1 vials. Regions of interest (ROIs) were drawn around tumors that were located within 50-100% iso-dose lines of maximum radiation dose. ROIs were also drawn at globus pallidus, thalamus, and cerebral white matter. Averages of R1 values (unit: s-1) before and after radiation and those of R1 ratio (post-radiation R1 / pre-radiation R1) were compared by t-test or rank sum test as appropriate. Multiple linear regression analysis was performed to evaluate independent association factors for R1 value increase at irradiated parenchyma. The mean R1 values in peri-tumoral areas were significantly increased after radiotherapy (0.7901±0.0977 [mean±SD] vs. 0.8146±0.1064; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0192838