Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Cardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the...

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Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0195166-e0195166
Main Authors: Benichou, Thomas, Pereira, Bruno, Mermillod, Martial, Tauveron, Igor, Pfabigan, Daniela, Maqdasy, Salwan, Dutheil, Frédéric
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis
Autonomic nervous system
Biology and Life Sciences
Blood pressure
Body Mass Index
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
Cognitive science
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Diabetic neuropathy
EKG
Electrocardiography
Endocrinology
Female
Glucose
Glucose metabolism
Health care
Heart diseases
Heart Rate
Hemoglobin
Hospitals
Human health and pathology
Humans
Hypertension
Intervals
Life Sciences
Male
Measurement
Medicine and Health Sciences
Meta-analysis
Metabolism
Middle Aged
Mortality
Neuropathy
Obesity
Parameters
Parasympathetic nervous system
Patients
Physiological aspects
Physiological research
Regression Analysis
Risk Factors
Systematic review
Task forces
Type 2 diabetes
Variability
Weight control
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Summary:Cardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. The PubMed, Cochrane Library, Embase and Science Direct databases were searched on 1st October 2017 using the keywords "diabetes" AND ("heart rate variability" OR "HRV"). Included articles had to report HRV parameters in T2DM patients and healthy controls measured during 24 hours with a Holter-electrocardiogram. Measurements of HRV retieved were: RR-intervals (or Normal to Normal intervals-NN), standard deviation of RR intervals (SDNN), percetange of adjacent NN intervals differing by more than 50 milliseconds (pNN50), square root of the mean squared difference of successive RR intervals (RMSSD), total power, Low Frequency (LF), High Frequency (HF) and LF/HF ratio, as per Task Force recommendations. We included twenty-five case-control studies with 2,932 patients: 1,356 with T2DM and 1,576 healthy controls. T2DM patients had significantly (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0195166