Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease

In chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk. The origin of these changes and their relationship with alterations in the pulmonary circulation are unknown. To investig...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e106163-e106163
Main Authors: Pizarro, Sandra, García-Lucio, Jéssica, Peinado, Víctor I, Tura-Ceide, Olga, Díez, Marta, Blanco, Isabel, Sitges, Marta, Petriz, Jordi, Torralba, Yolanda, Marín, Pedro, Roca, Josep, Barberà, Joan Albert
Format: Article
Language:English
Subjects:
AC133 Antigen
Aged
Angiogenesis
Antigens, CD - metabolism
Antigens, CD34 - metabolism
Arteries
Biology and Life Sciences
Bone marrow
C-reactive protein
Cardiovascular diseases
Case studies
CD34 antigen
CD45 antigen
Cells (biology)
Chronic obstructive pulmonary disease
Chronic obstructive pulmonary diseases
Cigarette smoking
Cytometry
Dilation
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Estudi de casos
Family medical history
Female
Fibrinogen
Flow cytometry
Glycoproteins - metabolism
Health risks
Hematopoietic stem cells
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - pathology
Hipertensió pulmonar
Hospitals
Humans
Hypertension
Hypertension, Pulmonary - metabolism
Hypertension, Pulmonary - pathology
Hypertension, Pulmonary - physiopathology
Hàbit de fumar
Impairment
Interleukin 6
Kinases
Leukocyte Common Antigens - metabolism
Lung diseases
Malalties cardiovasculars
Malalties pulmonars obstructives cròniques
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Middle Aged
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - physiopathology
Obstructive lung disease
Patients
Peptides - metabolism
Progenitor cells
Pulmonary arteries
Pulmonary circulation
Pulmonary Disease, Chronic Obstructive - metabolism
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary hypertension
Risk analysis
Risk factors
Smoking
Tobbacco habit
Tumor necrosis factor-TNF
Vascular endothelial growth factor
Veins & arteries
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Summary:In chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk. The origin of these changes and their relationship with alterations in the pulmonary circulation are unknown. To investigate whether changes in the number of circulating hematopoietic progenitor cells are associated with pulmonary hypertension or changes in endothelial function. 62 COPD patients and 35 controls (18 non-smokers and 17 smokers) without cardiovascular risk factors other than cigarette smoking were studied. The number of circulating progenitors was measured as CD45(+)CD34(+)CD133(+) labeled cells by flow cytometry. Endothelial function was assessed by flow-mediated dilation. Markers of inflammation and angiogenesis were also measured in all subjects. Compared with controls, the number of circulating progenitor cells was reduced in COPD patients. Progenitor cells did not differ between control smokers and non-smokers. COPD patients with pulmonary hypertension showed greater number of progenitor cells than those without pulmonary hypertension. Systemic endothelial function was worse in both control smokers and COPD patients. Interleukin-6, fibrinogen, high sensitivity C-reactive protein, vascular endothelial growth factor and tumor necrosis factor were increased in COPD. In COPD patients, the number of circulating progenitor cells was inversely related to the flow-mediated dilation of systemic arteries. Pulmonary and systemic vascular impairment in COPD is associated with cigarette smoking but not with the reduced number of circulating hematopoietic progenitors. The latter appears to be a consequence of the disease itself not related to smoking habit.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106163