Effect of transcranial direct-current stimulation combined with treadmill training on balance and functional performance in children with cerebral palsy: a double-blind randomized controlled trial

Cerebral palsy refers to permanent, mutable motor development disorders stemming from a primary brain lesion, causing secondary musculoskeletal problems and limitations in activities of daily living. The aim of the present study was to determine the effects of gait training combined with transcrania...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e105777-e105777
Main Authors: Duarte, Natália de Almeida Carvalho, Grecco, Luanda André Collange, Galli, Manuela, Fregni, Felipe, Oliveira, Cláudia Santos
Format: Article
Language:English
Subjects:
Activities of daily living
Analysis of Variance
Balance
Balances (scales)
Brain
Brain research
Cerebral palsy
Cerebral Palsy - physiopathology
Cerebral Palsy - therapy
Child
Child, Preschool
Children
Clinical trials
Combined Modality Therapy
Control methods
Cortex (motor)
Double-Blind Method
Double-blind studies
Electric currents
Electrical currents
Electrical stimulation of the brain
ESB
Exercise Test
Exercise Therapy - methods
Fitness equipment
Gait
Gait - physiology
Humans
Intervention
Learning
Medicine and Health Sciences
Motor Cortex - physiopathology
Motor task performance
Paralysis
Pediatrics
Physical therapy
Postural Balance - physiology
Posture
Psychomotor Performance - physiology
Randomization
Rehabilitation
Stimulation
Time Factors
Training
Transcranial Direct Current Stimulation - methods
Transcranial magnetic stimulation
Treadmills
Treatment Outcome
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Summary:Cerebral palsy refers to permanent, mutable motor development disorders stemming from a primary brain lesion, causing secondary musculoskeletal problems and limitations in activities of daily living. The aim of the present study was to determine the effects of gait training combined with transcranial direct-current stimulation over the primary motor cortex on balance and functional performance in children with cerebral palsy. A double-blind randomized controlled study was carried out with 24 children aged five to 12 years with cerebral palsy randomly allocated to two intervention groups (blocks of six and stratified based on GMFCS level (levels I-II or level III).The experimental group (12 children) was submitted to treadmill training and anodal stimulation of the primary motor cortex. The control group (12 children) was submitted to treadmill training and placebo transcranial direct-current stimulation. Training was performed in five weekly sessions for 2 weeks. Evaluations consisted of stabilometric analysis as well as the administration of the Pediatric Balance Scale and Pediatric Evaluation of Disability Inventory one week before the intervention, one week after the completion of the intervention and one month after the completion of the intervention. All patients and two examiners were blinded to the allocation of the children to the different groups. The experimental group exhibited better results in comparison to the control group with regard to anteroposterior sway (eyes open and closed; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0105777