Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis

To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Cross-sectional, observational study. The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0194169-e0194169
Main Authors: Nieves-Moreno, María, Martínez-de-la-Casa, José M, Morales-Fernández, Laura, Sánchez-Jean, Rubén, Sáenz-Francés, Federico, García-Feijoó, Julián
Format: Article
Language:English
Subjects:
Age
Analysis
Biology and Life Sciences
Care and treatment
Correlation analysis
Diabetes
Diabetic retinopathy
Diagnosis
Epithelium
Eye (anatomy)
Family medical history
Glaucoma
Hospitals
Longitudinal studies
Medicine
Medicine and Health Sciences
Ophthalmology
Optical Coherence Tomography
Optics
Physical Sciences
Regression analysis
Research and Analysis Methods
Retina
Retinal diseases
Retinal pigment epithelium
Segmentation
Sex
Social Sciences
Spectra
Thickness
Tomography
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Summary:To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Cross-sectional, observational study. The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years. In one randomly selected eye of each participant the volume and mean thicknesses of the different macular layers were measured by SD-OCT using the instrument's macular segmentation software. Volume and mean thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigmentary epithelium (RPE) and photoreceptor layer (PR). Retinal thickness was reduced by 0.24 μm for every one year of age. Age adjusted linear regression analysis revealed mean GCL, IPL, ONL and PR thickness reductions and a mean OPL thickness increase with age. Women had significantly lower mean GCL, IPL, INL, ONL and PR thicknesses and volumes and a significantly greater mRNFL volume than men. The thickness of most retinal layers varies both with age and according to sex. Longitudinal studies are needed to determine the rate of layer thinning produced with age.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0194169