Differences between fellow eyes of acute and chronic primary angle closure (glaucoma): An ultrasound biomicroscopy quantitative study

To compare various biometric parameters between fellow eyes of acute primary angle closure (glaucoma) [APAC(G)] and fellow eyes of chronic primary angle closure (glaucoma) [CPAC(G)]. Ultrasound biomicroscopy examinations were performed on 47 patients with unilateral APAC(G) and 41 patients with asym...

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Bibliographic Details
Published in:PloS one 2018-02, Vol.13 (2), p.e0193006-e0193006
Main Authors: Li, Mengwei, Chen, Yuhong, Chen, Xiaoxiao, Zhu, Wenqing, Chen, Xueli, Wang, Xiaolei, Fang, Yuan, Kong, Xiangmei, Dai, Yi, Chen, Junyi, Sun, Xinghuai
Format: Article
Language:English
Subjects:
Anterior chamber
Biology and Life Sciences
Biometrics
Care and treatment
Curvature
Development and progression
Eye
Eye lens
Glaucoma
Health risk assessment
Hospitals
Iris
Laboratories
MBA programs & graduates
Medical imaging
Medicine and Health Sciences
Methods
Neurosciences
Nuclear weapons
Patients
Pilocarpine
Regression analysis
Research and Analysis Methods
Tomography
Ultrasonic imaging
Ultrasonic testing
Ultrasound
Visual impairment
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Summary:To compare various biometric parameters between fellow eyes of acute primary angle closure (glaucoma) [APAC(G)] and fellow eyes of chronic primary angle closure (glaucoma) [CPAC(G)]. Ultrasound biomicroscopy examinations were performed on 47 patients with unilateral APAC(G) and 41 patients with asymmetric CPAC(G) before laser peripheral iridotomy and pilocarpine treatment. Anterior chamber depth and width (ACD and ACW), lens vault (LV), iris curvature (IC), iris root distance (IRD), trabecular-ciliary process distance (TCPD), iris-ciliary process distance (ICPD), trabecular-ciliary angle (TCA), and other biometric parameters were compared between fellow eyes of APAC(G) and fellow eyes of CAPC(G). Compared with fellow eyes of CPAC(G), fellow eyes of APAC(G) had smaller ACD (P < 0.001), ACW (P = 0.007), TCPD (P = 0.016), ICPD (P = 0.008), and TCA (P = 0.006), as well as larger LV (P = 0.002), IC (P = 0.012), and IRD (P = 0.003). On multivariate logistic regression analyses, a 0.1 mm decrease in ACD (odds ratio [OR]: 0.705, 95%CI: 0.564-0.880, P = 0.002), ICPD (OR: 0.557, 95%CI: 0.335-0.925, P = 0.024), and a 0.1 mm increase in IRD (OR: 2.707, 95%CI: 1.025-7.149, P = 0.045), was significantly associated with occurrence of acute angle closures. Fellow eyes of APAC(G) had smaller anterior segment dimensions, higher LV, more posterior iris insertion, greater IC, and more anteriorly rotated ciliary body compared with fellow eyes of CPAC(G). ACD, ICPD, and IRD were the three most important parameters that distinguish eyes predisposed to APAC(G) or CPAC(G).
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0193006