Procalcitonin for selecting the antibiotic regimen in outpatients with low-risk community-acquired pneumonia using a rapid point-of-care testing: A single-arm clinical trial

We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selectio...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0175634-e0175634
Main Authors: Masiá, Mar, Padilla, Sergio, Ortiz de la Tabla, Victoria, González, Matilde, Bas, Cristina, Gutiérrez, Félix
Format: Article
Language:English
Subjects:
Adult
Adults
Anti-Bacterial Agents - therapeutic use
Antibiotics
Azithromycin
Bacteremia
Bacterial infections
Biology and Life Sciences
Calcitonin - physiology
Clinical trials
Communities
Community-Acquired Infections - drug therapy
Comorbidity
Epidemiology
Female
Hospitals
Humans
Infectious diseases
Laboratories
Levofloxacin
Male
Medicine and Health Sciences
Middle Aged
Mortality
Outpatients
Pathogens
Patients
Pneumonia
Pneumonia - drug therapy
Point-of-Care Systems
Procalcitonin
Research and Analysis Methods
Risk
Sepsis
Streptococcus infections
Streptococcus pneumoniae
Systematic review
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Summary:We aimed to assess the role of procalcitonin (PCT) to guide the initial selection of the antibiotic regimen for low-risk community-acquired pneumonia (CAP). A single-arm clinical trial was conducted including outpatients with CAP and Pneumonia Severity Index risk classes I-II. Antimicrobial selection was based on the results of PCT measured with a rapid point-of-care testing. According to serum PCT levels, patients were assigned to two treatment strategies: oral azithromycin if PCT was
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0175634