A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis

Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported th...

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Published in:PLoS biology 2017-12, Vol.15 (12), p.e2002978-e2002978
Main Authors: Gao, Yi-Qun, Chen, Jiu-Geng, Chen, Zi-Ru, An, Dong, Lv, Qiao-Yan, Han, Mei-Ling, Wang, Ya-Ling, Salt, David E, Chao, Dai-Yin
Format: Article
Language:English
Subjects:
Arabidopsis
Arabidopsis thaliana
Biology
Biology and Life Sciences
Choline
Cloning
Data collection
Ecology
Endoplasmic reticulum
Gene expression
Homeostasis
Ion transport
Laboratories
Lipids
Medicine and Health Sciences
Mutation
Physical Sciences
Physiology
Plant growth
Plant sciences
Plasmodesmata
Protein transport
Proteins
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Summary:Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.2002978