Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway

Berberin, extracted from Chinese herbal medicine Coptis chinensis, has been found to have anti-tumor activities. However, the underlying mechanisms have not been fully elucidated. Our current study demonstrated that berberin inhibited the in vitro and in vivo growth, migration/invasion of CRC cells,...

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Published in:PloS one 2015-05, Vol.10 (5), p.e0123478-e0123478
Main Authors: Liu, Xuan, Ji, Qing, Ye, Naijing, Sui, Hua, Zhou, Lihong, Zhu, Huirong, Fan, Zhongze, Cai, Jianfeng, Li, Qi
Format: Article
Language:English
Subjects:
Acupuncture
Animals
Anticancer properties
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antitumor agents
Apoptosis
Berberine
Berberine - chemistry
Berberine - pharmacology
Berberine - therapeutic use
Breast cancer
Cell Line, Tumor
Cell migration
Cell Movement - drug effects
Chinese medicine
Colon - drug effects
Colon - metabolism
Colon - pathology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Coptis - chemistry
Cyclooxygenase 2 - genetics
Cyclooxygenase 2 - metabolism
Cyclooxygenase-2
Dinoprostone - genetics
Dinoprostone - metabolism
Gelatinase A
Gene Expression Regulation, Neoplastic - drug effects
Herbal medicine
Hospitals
Humans
In vivo methods and tests
Janus kinase 2
Janus Kinase 2 - genetics
Janus Kinase 2 - metabolism
Kinases
Male
Metastases
Metastasis
Mice, Inbred BALB C
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Neoplasm Invasiveness - prevention & control
Neoplasm Metastasis - drug therapy
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Oncology
Phosphorylation
Prostaglandin E2
Prostate
Rectum - drug effects
Rectum - metabolism
Rectum - pathology
Signal transduction
Signal Transduction - drug effects
Signaling
Stat3 protein
STAT3 Transcription Factor - genetics
STAT3 Transcription Factor - metabolism
Studies
Tumorigenesis
Tumors
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Items that cite this one
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Summary:Berberin, extracted from Chinese herbal medicine Coptis chinensis, has been found to have anti-tumor activities. However, the underlying mechanisms have not been fully elucidated. Our current study demonstrated that berberin inhibited the in vitro and in vivo growth, migration/invasion of CRC cells, via attenuating the expression levels of COX-2/PGE2, following by reducing the phosphorylation of JAK2 and STAT3, as well as the MMP-2/-9 expression. We further clarified that an increase of COX-2/PGE2 expression offset the repressive activity of Berberin on JAK2/STAT3 signaling, and a JAK2 inhibitor AZD1480 blocked the effect of COX-2/PGE2 on MMP-2/-9 expression. In summary, Berberin inhibited CRC invasion and metastasis via down-regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0123478