Long-chain n-3 and n-6 polyunsaturated fatty acids and risk of atrial fibrillation: Results from a Danish cohort study

Studies of the relation between polyunsaturated fatty acids and risk of atrial fibrillation have been inconclusive. The risk of atrial fibrillation may depend on the interaction between n-3 and n-6 polyunsaturated fatty acids as both types of fatty acids are involved in the regulation of systemic in...

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Published in:	PloS one 2017-12, Vol.12 (12), p.e0190262-e0190262
Main Authors:	Mortensen, Lotte Maxild, Lundbye-Christensen, Søren, Schmidt, Erik Berg, Calder, Philip C, Schierup, Mikkel Heide, Tjønneland, Anne, Parner, Erik T, Overvad, Kim
Format:	Article
Language:	eng
Subjects:	Aged Atrial fibrillation Atrial Fibrillation - prevention & control Biology and Life Sciences Cancer Cardiac arrhythmia Cardiology Cardiovascular disease Chains Cohort Studies Cytokines Data collection Denmark Development and progression Diet Dietary intake Epidemiology Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-6 - administration & dosage Female Fibrillation Genetic aspects Health risks Heart attacks Heart failure Hospitals Humans Inflammation Linoleic acid Linolenic acid Male Medical research Medicine and Health Sciences Middle Aged Physiological aspects Polyunsaturated fatty acids Public health Research and Analysis Methods Risk Risk Factors Studies Survival analysis Systematic review Unsaturated fatty acids
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Summary:	Studies of the relation between polyunsaturated fatty acids and risk of atrial fibrillation have been inconclusive. The risk of atrial fibrillation may depend on the interaction between n-3 and n-6 polyunsaturated fatty acids as both types of fatty acids are involved in the regulation of systemic inflammation. We investigated the association between dietary intake of long chain polyunsaturated fatty acids (individually and in combination) and the risk of atrial fibrillation with focus on potential interaction between the two types of polyunsaturated fatty acids. The risk of atrial fibrillation in the Diet, Cancer and Health Cohort was analyzed using the pseudo-observation method to explore cumulative risks on an additive scale providing risk differences. Dietary intake of long chain polyunsaturated fatty acids was assessed by food frequency questionnaires. The main analyses were adjusted for the dietary intake of n-3 α-linolenic acid and n-6 linoleic acid to account for endogenous synthesis of long chain polyunsaturated fatty acids. Interaction was assessed as deviation from additivity of absolute association measures (risk differences). Cumulative risks in 15-year age periods were estimated in three strata of the cohort (N = 54,737). No associations between intake of n-3 or n-6 long chain polyunsaturated fatty acids and atrial fibrillation were found, neither when analyzed separately as primary exposures nor when interaction between n-3 and n-6 long chain polyunsaturated fatty acids was explored. This study suggests no association between intake of long chain polyunsaturated fatty acids and risk of atrial fibrillation.
ISSN:	1932-6203 1932-6203