Whole blood transcriptional profiling reveals deregulation of oxidative and antioxidative defence genes in myelofibrosis and related neoplasms. Potential implications of downregulation of Nrf2 for genomic instability and disease progression

The Philadelphia-negative chronic myeloproliferative neoplasms - essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) (MPNs) - have recently been shown to be associated with chronic inflammation, oxidative stress and accumulation of reactive oxygen species (ROS). Using whol...

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Bibliographic Details

Published in:	PloS one 2014-11, Vol.9 (11), p.e112786-e112786
Main Authors:	Hasselbalch, Hans Carl, Thomassen, Mads, Riley, Caroline Hasselbalch, Kjær, Lasse, Larsen, Thomas Stauffer, Jensen, Morten K, Bjerrum, Ole Weis, Kruse, Torben A, Skov, Vibe
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Antigens Biology and Life Sciences Blood Blood Proteins - metabolism Cancer Cancer genetics Cell migration CXCR4 protein Datasets Denmark Deoxyribonucleic acid Deregulation Development and progression Disease Disease Progression DNA DNA methylation Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - physiology Genes Genetic aspects Genetic transcription Genomic instability Genomic Instability - genetics Genomic Instability - physiology Hematology Hematopoietic stem cells Humans Hypothesis testing Inflammation Lymphoma Lymphomas Male Medicine and Health Sciences Middle Aged Mitochondrial uncoupling protein 2 Mutation Myelofibrosis Myeloproliferative Disorders - metabolism Neoplasms NF-E2-Related Factor 2 - metabolism NRF2 protein Oxidative stress Oxygen Patients Polycythemia Polycythemia vera Profiling Reactive oxygen species Receptors, CXCR4 - metabolism Stability Stem cells Transcription (Genetics) Tumors
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