Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis

The joint effect of the interaction of alcohol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) on the risk of cirrhosis is still unexplored because a large sample size is required for this investigation. Evaluation of interaction of HBV, HCV and alcohol abuse on the risk of cirrhosis. We...

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Bibliographic Details
Published in:PloS one 2017-11, Vol.12 (11), p.e0185710-e0185710
Main Authors: Stroffolini, Tommaso, Sagnelli, Evangelista, Andriulli, Angelo, Colloredo, Guido, Furlan, Caterina, Gaeta, Giovanni Battista, Morisco, Filomena, Pirisi, Mario, Rosina, Floriano, Sagnelli, Caterina, Smedile, Antonina, Almasio, Piero Luigi
Format: Article
Language:English
Subjects:
Abuse
Alcohol abuse
Alcohol use
Alcoholic beverages
Apoptosis
Biology and Life Sciences
Biopsy
Body mass
Cirrhosis
Drinking (Alcoholic beverages)
Drug abuse
Ethics
Females
Gastroenterology
Gender
Health aspects
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis B virus
Hepatitis C
Hepatitis C virus
Hepatology
Histology
Hospitals
Infections
Infectious diseases
Internal medicine
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Males
Medicine and Health Sciences
Mental health
Metabolism
Patients
Preventive medicine
Regression analysis
Risk
Risk factors
Sex
Sex differences
Sex differences (Biology)
Ultrasonic imaging
Viral infections
Viruses
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Summary:The joint effect of the interaction of alcohol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) on the risk of cirrhosis is still unexplored because a large sample size is required for this investigation. Evaluation of interaction of HBV, HCV and alcohol abuse on the risk of cirrhosis. We analysed 12,262 consecutive patients with chronic liver disease of various aetiologies referring to 95 Italian liver units in 2001 or 2014. To evaluate the interaction between alcohol abuse, HBV infection, and HCV infection, patients unexposed to either factors were used as reference category. Adjustment for BMI and age was done by multiple logistic regression analysis. Females were older than males (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0185710